| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $60,356 | -40.2% | 20 | - | $3,017 | $200,831 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Knowing | $46,277 | - | 8 | - | $5,784 | $46,277 | 1 | N/A | true | false |
| 3 | - | Night at the Museum: Battle of the Smithsonian | $22,049 | - | 9 | - | $2,449 | $22,049 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Star Trek | $15,078 | -49.9% | 11 | - | $1,370 | $149,618 | 3 | United International Pictures | false | false |
| 5 | - | The Unborn | $6,484 | - | 5 | - | $1,296 | $6,484 | 1 | United International Pictures | true | false |
| 6 | 5 | Coraline | $5,595 | -36.4% | 9 | +1 | $621 | $16,494 | 2 | United International Pictures | false | false |
| 7 | 6 | Monsters vs. Aliens | $5,147 | -33.1% | 12 | - | $428 | $215,345 | 8 | United International Pictures | false | false |
| 8 | 3 | 17 Again | $4,069 | -64.3% | 5 | -1 | $813 | $73,144 | 4 | Warner Bros. | false | false |
| 9 | 4 | X-Men Origins: Wolverine | $3,758 | -66.6% | 8 | - | $469 | $113,298 | 4 | Continental Film | false | false |
| 10 | 8 | Gran Torino | $2,287 | -34.1% | 4 | -2 | $571 | $90,409 | 6 | Warner Bros. | false | false |
| 11 | 7 | State of Play | $1,764 | -64.9% | 3 | -3 | $588 | $38,376 | 4 | United International Pictures | false | false |
| 12 | 10 | The Reader | $1,689 | -47.8% | 4 | - | $422 | $53,589 | 7 | N/A | false | false |
| 13 | 11 | I Love You, Man | $1,589 | -46.6% | 5 | - | $317 | $54,019 | 5 | United International Pictures | false | false |
| 14 | 12 | Zack and Miri Make a Porno | $1,504 | -49% | 3 | - | $501 | $12,191 | 3 | N/A | false | false |
| 15 | 9 | Fast & Furious | $1,117 | -65.7% | 3 | -2 | $372 | $204,287 | 7 | United International Pictures | false | false |
