| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $1,475,214 | -0.4% | 132 | - | $11,175 | $3,778,280 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Night at the Museum: Battle of the Smithsonian | $698,293 | - | 101 | - | $6,913 | $799,361 | 1 | Warner Bros. | true | false |
| 3 | - | Fighting | $206,448 | - | 39 | - | $5,293 | $220,637 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Star Trek | $193,215 | -25.1% | 76 | - | $2,542 | $1,116,890 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | 17 Again | $182,299 | +0.7% | 70 | - | $2,604 | $1,884,940 | 5 | RCV Film Distribution | false | false |
| 6 | 3 | X-Men Origins: Wolverine | $158,787 | -28.9% | 91 | -11 | $1,744 | $2,469,789 | 4 | Warner Bros. | false | false |
| 7 | 5 | He's Just Not That Into You | $81,938 | -15% | 51 | -27 | $1,606 | $1,660,725 | 6 | Paradiso Entertainment | false | false |
| 8 | 7 | The Reader | $67,228 | -16% | 34 | -1 | $1,977 | $1,572,864 | 8 | Benelux Film Distributors | false | false |
| 9 | 6 | Coraline | $65,682 | -22.6% | 90 | +1 | $729 | $181,297 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 10 | Sunshine Cleaning | $60,787 | -12.4% | 25 | - | $2,431 | $195,119 | 2 | A-Film Distribution | false | false |
| 11 | 12 | Slumdog Millionaire | $60,766 | -3.6% | 48 | - | $1,265 | $5,052,791 | 15 | Cinéart | false | false |
| 12 | 9 | Monsters vs. Aliens | $58,174 | -17.8% | 112 | -2 | $519 | $2,007,814 | 8 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Beverly Hills Chihuahua | $57,234 | -12.3% | 60 | - | $953 | $716,904 | 5 | Walt Disney Pictures | false | false |
| 14 | 8 | Knowing | $51,713 | -28.6% | 44 | -14 | $1,175 | $1,522,466 | 7 | Independent Films | false | false |
| 15 | - | The Young Victoria | $42,022 | - | 22 | - | $1,910 | $56,668 | 1 | Paradiso Entertainment | true | false |
| 16 | 13 | The Last Days of Emma Blank | $40,866 | -21% | 22 | - | $1,857 | $206,394 | 3 | A-Film Distribution | false | false |
| 17 | 14 | The Haunting in Connecticut | $26,002 | -22.1% | 14 | -5 | $1,857 | $280,327 | 4 | Benelux Film Distributors | false | false |
| 18 | 15 | Lemo | $25,771 | -18.4% | 88 | -9 | $292 | $652,168 | 7 | Independent Films | false | false |
| 19 | - | Casanegra | $20,108 | - | 3 | - | $6,702 | $20,108 | 1 | Moonlight Films | true | false |
| 20 | 17 | Eden Lake | $15,864 | -42.7% | 7 | - | $2,266 | $77,707 | 2 | Benelux Film Distributors | false | false |
