| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $370,951 | -24.4% | 154 | -11 | $2,408 | $1,113,093 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Angels & Demons | $308,927 | -31.3% | 110 | - | $2,808 | $1,937,008 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Righteous Kill | $72,660 | - | 54 | - | $1,345 | $72,660 | 1 | Cine Colombia | true | false |
| 4 | - | Duplicity | $54,254 | - | 25 | - | $2,170 | $54,254 | 1 | United International Pictures | true | false |
| 5 | 3 | X-Men Origins: Wolverine | $51,841 | -38.7% | 72 | -16 | $720 | $1,488,246 | 5 | 20th Century Fox International | false | false |
| 6 | 4 | Hannah Montana: The Movie | $31,037 | -33.5% | 43 | -5 | $721 | $495,940 | 5 | Walt Disney Pictures | false | false |
| 7 | 5 | The Unborn | $27,359 | -24.5% | 29 | -7 | $943 | $292,263 | 4 | United International Pictures | false | false |
| 8 | 8 | Monsters vs. Aliens | $15,496 | -16.8% | 35 | +30 | $442 | $1,960,499 | 9 | United International Pictures | false | false |
| 9 | 7 | Star Trek | $12,131 | -55% | 23 | -17 | $527 | $254,759 | 4 | United International Pictures | false | false |
| 10 | 6 | The Strangers | $12,092 | -62.5% | 21 | -12 | $575 | $66,062 | 2 | Cine Colombia | false | false |
| 11 | - | Funny Games | $9,177 | - | 12 | - | $764 | $9,177 | 1 | Cine Colombia | true | false |
| 12 | 9 | Venus 2009 Re-release | $8,372 | -9.8% | 3 | -2 | $2,790 | $23,623 | 2 | Cine Colombia | false | false |
| 13 | - | Happy-Go-Lucky | $7,397 | - | 9 | - | $821 | $7,397 | 1 | Cineplex | true | false |
| 14 | 12 | Earth | $6,601 | +3.6% | 19 | +3 | $347 | $213,314 | 6 | Walt Disney Pictures | false | false |
| 15 | 14 | Knowing | $6,307 | +156.7% | 4 | -1 | $1,576 | $632,375 | 7 | Cine Colombia | false | false |
| 16 | 11 | Paul Blart: Mall Cop | $3,887 | -42.2% | 12 | -8 | $323 | $138,491 | 4 | Sony Pictures Releasing | false | false |
| 17 | 13 | Frozen River | $3,872 | -39.2% | 3 | - | $1,290 | $14,701 | 2 | Sony Pictures Releasing | false | false |
| 18 | 15 | Race to Witch Mountain | $1,615 | +18.2% | 8 | -11 | $201 | $1,324,850 | 10 | Walt Disney Pictures | false | false |
| 19 | 16 | Milk | $456 | -66.2% | 1 | -2 | $456 | $102,648 | 6 | United International Pictures | false | false |
| 20 | 18 | Rachel Getting Married | $343 | -60.4% | 1 | -2 | $343 | $29,014 | 13 | Sony Pictures Releasing | false | false |
