| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $227,451 | +1.3% | 41 | +12 | $5,547 | $1,137,853 | 3 | Falcon | false | false |
| 2 | 2 | Night at the Museum: Battle of the Smithsonian | $178,794 | +55.6% | 25 | +1 | $7,151 | $329,439 | 2 | Bontonfilm | false | false |
| 3 | - | Jménem krále | $72,745 | - | 23 | - | $3,162 | $72,745 | 1 | Bioscop | true | false |
| 4 | - | New in Town | $50,849 | - | 18 | - | $2,824 | $53,839 | 1 | SPI International | true | false |
| 5 | 7 | Monsters vs. Aliens | $47,274 | +192.4% | 31 | +2 | $1,524 | $886,094 | 10 | Bontonfilm | false | false |
| 6 | - | State of Play | $45,653 | - | 23 | - | $1,984 | $46,421 | 1 | Bontonfilm | true | false |
| 7 | 3 | Star Trek | $42,158 | +1.2% | 23 | -1 | $1,832 | $426,206 | 4 | Bontonfilm | false | false |
| 8 | 5 | Líbás jako buh | $39,810 | +94.1% | 25 | +1 | $1,592 | $4,512,104 | 16 | Falcon | false | false |
| 9 | 4 | My Bloody Valentine | $35,105 | +18.1% | 15 | -2 | $2,340 | $380,932 | 5 | Bioscop | false | false |
| 10 | 6 | 17 Again | $18,625 | +1.9% | 27 | -2 | $689 | $150,567 | 4 | Warner Bros. | false | false |
| 11 | 11 | Duplicity | $11,723 | +3.5% | 15 | -6 | $781 | $116,017 | 4 | Bontonfilm | false | false |
| 12 | 8 | X-Men Origins: Wolverine | $11,629 | -27.1% | 25 | -3 | $465 | $288,976 | 5 | Bontonfilm | false | false |
| 13 | 9 | The Last House on the Left | $11,021 | -18.1% | 25 | +1 | $440 | $32,304 | 2 | Bontonfilm | false | false |
| 14 | 12 | Slumdog Millionaire | $10,948 | +33.2% | 12 | -2 | $912 | $880,861 | 14 | Bontonfilm | false | false |
| 15 | 10 | The Reader | $10,913 | -4.9% | 7 | - | $1,559 | $202,427 | 6 | Palace Films | false | false |
| 16 | 17 | Bolt | $8,452 | +200.9% | 12 | +1 | $704 | $632,680 | 15 | Falcon | false | false |
| 17 | - | Bottle Shock | $8,090 | - | 6 | - | $1,348 | $11,172 | 1 | Palace Films | true | false |
| 18 | 19 | Fly Me to the Moon 3D | $7,534 | +243.9% | 6 | -2 | $1,255 | $1,048,245 | 20 | Intersonic | false | false |
| 19 | 13 | A Man and His Dog | $6,704 | -15.2% | 11 | - | $609 | $18,510 | 2 | - | false | false |
| 20 | - | The Tale of Despereaux | $3,906 | - | 9 | - | $434 | $266,986 | 17 | Bontonfilm | false | false |
