| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $756,087 | -48.7% | 132 | - | $5,727 | $4,946,868 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Night at the Museum: Battle of the Smithsonian | $301,769 | -56.8% | 101 | - | $2,987 | $1,268,896 | 2 | Warner Bros. | false | false |
| 3 | - | Duplicity | $130,062 | - | 38 | - | $3,422 | $159,542 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | Coco Before Chanel | $102,751 | - | 30 | - | $3,425 | $189,767 | 1 | RCV Film Distribution | true | false |
| 5 | 4 | Star Trek | $85,167 | -55.9% | 74 | -2 | $1,150 | $1,261,617 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | 3 | Fighting | $83,092 | -59.8% | 39 | - | $2,130 | $359,504 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 5 | 17 Again | $76,392 | -58.1% | 70 | - | $1,091 | $2,026,072 | 6 | RCV Film Distribution | false | false |
| 8 | - | I Love You, Man | $75,040 | - | 29 | - | $2,587 | $81,992 | 1 | Universal Pictures International (UPI) | true | false |
| 9 | 6 | X-Men Origins: Wolverine | $66,916 | -57.9% | 73 | -18 | $916 | $2,602,403 | 5 | Warner Bros. | false | false |
| 10 | 8 | The Reader | $41,681 | -38% | 36 | +2 | $1,157 | $1,654,152 | 9 | Benelux Film Distributors | false | false |
| 11 | 11 | Slumdog Millionaire | $34,885 | -42.6% | 48 | - | $726 | $5,158,179 | 16 | Cinéart | false | false |
| 12 | 7 | He's Just Not That Into You | $32,403 | -60.5% | 39 | -12 | $830 | $1,731,596 | 7 | Paradiso Entertainment | false | false |
| 13 | 10 | Sunshine Cleaning | $25,417 | -58.2% | 25 | - | $1,016 | $242,769 | 3 | A-Film Distribution | false | false |
| 14 | 16 | The Last Days of Emma Blank | $24,581 | -39.8% | 22 | - | $1,117 | $247,528 | 4 | A-Film Distribution | false | false |
| 15 | - | The Brothers Bloom | $22,360 | - | 20 | - | $1,118 | $52,882 | 1 | A-Film Distribution | true | false |
| 16 | 15 | The Young Victoria | $22,094 | -47.4% | 22 | - | $1,004 | $96,412 | 2 | Paradiso Entertainment | false | false |
| 17 | 14 | Knowing | $21,332 | -58.7% | 32 | -12 | $666 | $1,569,491 | 8 | Independent Films | false | false |
| 18 | 12 | Monsters vs. Aliens | $21,007 | -63.9% | 109 | -3 | $192 | $2,063,893 | 9 | Universal Pictures International (UPI) | false | false |
| 19 | 9 | Coraline | $17,851 | -72.8% | 79 | -11 | $225 | $215,134 | 3 | Universal Pictures International (UPI) | false | false |
| 20 | 13 | Beverly Hills Chihuahua | $15,682 | -72.6% | 60 | - | $261 | $758,283 | 6 | Walt Disney Pictures | false | false |
