| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $324,121 | -17.2% | 72 | -1 | $4,501 | $795,906 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Angels & Demons | $271,229 | -15.4% | 77 | -3 | $3,522 | $1,458,269 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | Star Trek | $147,659 | -23.8% | 56 | +3 | $2,636 | $1,561,413 | 4 | Paramount Pictures International | false | false |
| 4 | - | State of Play | $118,343 | - | 44 | - | $2,689 | $118,343 | 1 | United International Pictures | true | false |
| 5 | - | I Love You, Man | $118,264 | - | 39 | - | $3,032 | $118,264 | 6 | Paramount Pictures International | false | false |
| 6 | - | Paul Blart: Mall Cop | $101,995 | - | 35 | - | $2,914 | $101,995 | 1 | Sony Pictures Releasing | true | false |
| 7 | - | Easy Virtue | $94,938 | - | 36 | - | $2,637 | $99,100 | 1 | Hopscotch Films | true | false |
| 8 | 4 | Knowing | $88,146 | -39.1% | 47 | -1 | $1,875 | $296,867 | 2 | Hoyts Distribution | false | false |
| 9 | 5 | X-Men Origins: Wolverine | $57,017 | -30% | 52 | -12 | $1,096 | $1,672,208 | 5 | 20th Century Fox International | false | false |
| 10 | 6 | The Topp Twins: Untouchable Girls | $38,827 | -30.5% | 58 | +1 | $669 | $1,027,127 | 8 | Rialto Distribution | false | false |
| 11 | 9 | I've Loved You So Long | $28,761 | -8.9% | 3 | -6 | $9,587 | $121,922 | 3 | Palace Films | false | false |
| 12 | 7 | Last Chance Harvey | $27,758 | -43.4% | 40 | -7 | $693 | $565,387 | 5 | Hoyts Distribution | false | false |
| 13 | 18 | Bottle Shock | $27,717 | +203.4% | 20 | +4 | $1,385 | $37,532 | 2 | Roadshow Films | false | false |
| 14 | 11 | The Reader | $17,547 | -14.3% | 16 | -3 | $1,096 | $733,561 | 8 | Roadshow Films | false | false |
| 15 | 10 | Defiance | $17,136 | -43% | 23 | -8 | $745 | $416,049 | 5 | Roadshow Films | false | false |
| 16 | 13 | A Film with Me in It | $14,381 | -18.8% | 19 | - | $756 | $39,306 | 2 | Vendetta Films | false | false |
| 17 | 8 | Ghosts of Girlfriends Past | $12,977 | -65.2% | 24 | -18 | $540 | $348,771 | 4 | Roadshow Films | false | false |
| 18 | 12 | The Grocer's Son | $11,062 | -43.8% | 13 | +1 | $850 | $181,772 | 6 | Rialto Distribution | false | false |
| 19 | - | The Escapist | $10,659 | - | 6 | - | $1,776 | $24,135 | 1 | Rialto Distribution | true | false |
| 20 | 14 | In Search of Beethoven | $9,556 | -43% | 21 | -7 | $455 | $56,297 | 3 | - | false | false |
