| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $156,907 | -30.8% | 95 | -7 | $1,651 | $1,161,440 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Night at the Museum: Battle of the Smithsonian | $59,869 | -26.1% | 22 | -5 | $2,721 | $161,747 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Ghosts of Girlfriends Past | $17,296 | -22% | 13 | - | $1,330 | $51,422 | 2 | Warner Bros. | false | false |
| 4 | - | Duplicity | $13,582 | - | 11 | - | $1,234 | $13,582 | 1 | United International Pictures | true | false |
| 5 | 4 | Hannah Montana: The Movie | $8,780 | -42.6% | 10 | -2 | $878 | $56,389 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | X-Men Origins: Wolverine | $3,631 | -51.2% | 8 | -6 | $453 | $247,666 | 5 | 20th Century Fox International | false | false |
| 7 | 7 | Knowing | $3,124 | -55.5% | 5 | -1 | $624 | $58,926 | 4 | N/A | false | false |
| 8 | 8 | Star Trek | $2,581 | -19.7% | 1 | -1 | $2,581 | $51,748 | 4 | United International Pictures | false | false |
| 9 | 6 | The Unborn | $1,637 | -76.8% | 7 | -6 | $233 | $86,425 | 4 | United International Pictures | false | false |
| 10 | 9 | Paul Blart: Mall Cop | $881 | -56.7% | 2 | -3 | $440 | $234,037 | 8 | Sony Pictures Releasing | false | false |
| 11 | 10 | Doubt | $630 | -63.3% | 1 | -1 | $630 | $10,434 | 3 | Walt Disney Pictures | false | false |
| 12 | 14 | 17 Again | $74 | +54.2% | 1 | - | $74 | $81,411 | 6 | Warner Bros. | false | false |
