| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $3,875,013 | - | 542 | - | $7,149 | $3,875,013 | 1 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | true | false |
| 2 | 1 | Night at the Museum: Battle of the Smithsonian | $2,087,808 | -60.1% | 883 | - | $2,364 | $8,896,835 | 2 | 20th Century Fox International | false | false |
| 3 | 2 | Angels & Demons | $748,218 | -70% | 453 | -232 | $1,651 | $12,698,000 | 3 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 4 | - | 17 Again | $676,601 | - | 279 | - | $2,425 | $676,601 | 1 | Karo Premiere | true | false |
| 5 | 3 | The Way | $150,809 | -61.1% | 339 | - | $444 | $681,053 | 2 | N/A | false | false |
| 6 | 4 | The Last House on the Left | $145,060 | -46.2% | 170 | -3 | $853 | $539,114 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | - | 100 Feet | $67,377 | - | 70 | - | $962 | $67,377 | 1 | - | true | false |
| 8 | - | Krabat and the Legend of the Satanic Mill | $59,066 | - | 98 | - | $602 | $59,066 | 1 | Volga | true | false |
| 9 | 6 | Star Trek | $31,009 | -82.3% | 130 | -183 | $238 | $4,082,789 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 14 | Monsters vs. Aliens | $23,924 | +44.2% | 6 | -1 | $3,987 | $13,523,812 | 11 | Central Partnership | false | false |
| 11 | 27 | Beverly Hills Chihuahua | $19,369 | +795.9% | 8 | -3 | $2,421 | $653,911 | 8 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 12 | 9 | X-Men Origins: Wolverine | $17,983 | -72.4% | 58 | -100 | $310 | $7,629,749 | 5 | 20th Century Fox International | false | false |
| 13 | 11 | De l'autre côté du lit | $14,962 | -47.3% | 31 | -2 | $482 | $436,605 | 4 | Cascade Film | false | false |
| 14 | 10 | The Boat That Rocked | $14,308 | -63.1% | 29 | -33 | $493 | $1,036,117 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | - | French Film | $12,886 | - | 2 | - | $6,443 | $12,886 | 1 | Russian Report | true | false |
| 16 | 7 | Observe and Report | $8,786 | -93.7% | 48 | -208 | $183 | $748,635 | 3 | Karo Premiere | false | false |
| 17 | - | While She Was Out | $8,306 | - | 11 | - | $755 | $94,233 | 4 | - | false | false |
| 18 | 5 | Battle for Terra | $8,135 | -96% | 17 | -68 | $478 | $678,395 | 3 | Luxor Entertainment | false | false |
| 19 | 12 | Newsmakers | $5,706 | -76.4% | 21 | -57 | $271 | $622,622 | 4 | Cinema Without Frontiers | false | false |
| 20 | 28 | Killshot | $4,938 | +150.2% | 27 | +7 | $182 | $152,166 | 4 | West Video | false | false |
| 21 | 16 | Disgrace | $4,802 | -54.8% | 5 | -1 | $960 | $18,789 | 2 | CP Classics | false | false |
| 22 | 8 | Coraline | $4,723 | -94.6% | 8 | -48 | $590 | $1,717,794 | 5 | Universal Pictures International (UPI) | false | false |
| 23 | 19 | Milk | $4,382 | -23.1% | 14 | -4 | $313 | $333,695 | 6 | Paradise Group | false | false |
| 24 | - | The Man Who Loves | $4,302 | - | 6 | - | $717 | $283,353 | 5 | - | false | false |
| 25 | - | The Tribute to Pavarotti | $3,936 | - | 29 | - | $135 | $23,044 | 1 | N/A | true | false |
| 26 | 22 | Dead Snow | $3,900 | +2.1% | 14 | +2 | $278 | $78,177 | 4 | Volga | false | false |
| 27 | 15 | Zift | $3,795 | -64.3% | 5 | - | $759 | $16,334 | 2 | Cinema Without Frontiers | false | false |
| 28 | 17 | Taras Bulba | $3,486 | -54.7% | 21 | -11 | $166 | $16,988,388 | 9 | Central Partnership | false | false |
| 29 | 26 | Easy Virtue | $2,817 | +19.5% | 2 | - | $1,408 | $1,042,030 | 9 | Paradise Group | false | false |
| 30 | 24 | The Beautiful Person | $2,802 | -14.8% | 2 | - | $1,401 | $26,532 | 5 | Russian Report | false | false |
| 31 | 35 | He's Just Not That Into You | $2,634 | +331.1% | 3 | +2 | $878 | $2,863,198 | 9 | Karo Premiere | false | false |
| 32 | 18 | The Uninvited | $2,160 | -70.2% | 14 | -18 | $154 | $1,124,190 | 5 | Central Partnership | false | false |
| 33 | 38 | Tokyo! | $1,875 | +296.4% | 5 | +4 | $375 | $41,100 | 5 | CP Classics | false | false |
| 34 | 13 | Dark Planet: Rebellion | $1,793 | -92.6% | 11 | -19 | $163 | $6,069,159 | 6 | Karoprokat | false | false |
| 35 | - | Room and a Half | $1,670 | - | 2 | - | $835 | $40,346 | 8 | Paradise Group | false | false |
| 36 | 25 | Make It Happen | $1,062 | -63.4% | 7 | -17 | $151 | $492,825 | 7 | West Video | false | false |
| 37 | 33 | Gran Torino | $663 | -20% | 2 | +1 | $331 | $382,721 | 8 | Karo Premiere | false | false |
| 38 | - | Caution, Kids! | $522 | - | 4 | - | $130 | $117,965 | 6 | - | false | false |
| 39 | 29 | Crank: High Voltage | $493 | -73.6% | 8 | -17 | $61 | $6,461,647 | 7 | Central Partnership | false | false |
| 40 | - | A Summer in Genoa | $433 | - | 1 | - | $433 | $40,536 | 9 | Russian Report | false | false |
| 41 | 32 | Race to Witch Mountain | $400 | -62.2% | 9 | -4 | $44 | $1,837,532 | 10 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 42 | 30 | Synecdoche, New York | $286 | -80.2% | 3 | -1 | $95 | $54,377 | 8 | CP Classics | false | false |
| 43 | 20 | My Bloody Valentine | $249 | -94.5% | 1 | -1 | $249 | $2,061,380 | 8 | Central Partnership | false | false |
| 44 | - | Flashbacks of a Fool | $242 | - | 1 | - | $242 | $55,110 | 27 | Russian Report | false | false |
| 45 | - | Tonight I'll Sleep at Yours 2009 Re-release | $203 | - | 1 | - | $203 | $111,961 | 22 | Russian Report | false | false |
