| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $5,150,025 | - | 386 | - | $13,342 | $5,177,426 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Night at the Museum: Battle of the Smithsonian | $1,831,755 | -31.8% | 379 | -18 | $4,833 | $9,560,245 | 3 | 20th Century Fox International | false | false |
| 3 | - | I Love You, Man | $1,242,507 | - | 186 | - | $6,680 | $1,562,810 | 1 | Paramount Pictures International | true | false |
| 4 | 3 | State of Play | $1,019,861 | -35.7% | 245 | +3 | $4,162 | $3,212,362 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 2 | Angels & Demons | $979,916 | -40.9% | 348 | -77 | $2,815 | $12,214,120 | 4 | Sony Pictures Releasing | false | false |
| 6 | 4 | Star Trek | $532,764 | -46.1% | 229 | -57 | $2,326 | $11,542,175 | 5 | Paramount Pictures International | false | false |
| 7 | 8 | Samson & Delilah | $234,893 | +7.3% | 38 | +19 | $6,181 | $1,294,749 | 5 | Paramount Pictures International | false | false |
| 8 | 6 | Ghosts of Girlfriends Past | $229,096 | -45.4% | 137 | -51 | $1,672 | $4,879,494 | 5 | Roadshow Films | false | false |
| 9 | 5 | X-Men Origins: Wolverine | $218,531 | -54.5% | 160 | -71 | $1,365 | $14,449,021 | 6 | 20th Century Fox International | false | false |
| 10 | 9 | My Year Without Sex | $123,806 | -12.8% | 25 | - | $4,952 | $360,981 | 3 | Paramount Pictures International | false | false |
| 11 | - | Is Anybody There? | $111,293 | - | 32 | - | $3,477 | $131,113 | 1 | Hopscotch Films | true | false |
| 12 | 11 | The Boy in the Striped Pajamas | $68,804 | -33.5% | 71 | -33 | $969 | $2,759,465 | 7 | Walt Disney Pictures | false | false |
| 13 | 10 | Defiance | $44,691 | -61.5% | 61 | -45 | $732 | $2,821,258 | 6 | Roadshow Films | false | false |
| 14 | - | Sunshine Cleaning | $37,248 | - | 50 | - | $744 | $37,248 | - | Madman Entertainment | - | false |
| 15 | 16 | Gomorrah | $33,726 | -27.3% | 19 | +2 | $1,775 | $311,072 | 4 | Madman Entertainment | false | false |
| 16 | 14 | What Just Happened | $30,482 | -50.8% | 37 | +2 | $823 | $304,421 | 3 | Hopscotch Films | false | false |
| 17 | - | Under the Sea 3D | $29,035 | - | 2 | - | $14,517 | $585,612 | 15 | IMAX | false | false |
| 18 | - | Two Lovers | $28,680 | - | 3 | - | $9,560 | $28,680 | 1 | Roadshow Films | true | false |
| 19 | 15 | Adventureland | $24,405 | -49.9% | 19 | -22 | $1,284 | $95,215 | 2 | Roadshow Films | false | false |
| 20 | 18 | Monsters vs. Aliens | $19,845 | -28.1% | 38 | +3 | $522 | $16,257,222 | 10 | Paramount Pictures International | false | false |
| 21 | - | The Alps | $12,983 | - | 1 | - | $12,983 | $13,467 | 1 | IMAX | true | false |
| 22 | - | Fanboys | $2,109 | - | 1 | - | $2,109 | $2,109 | 1 | Roadshow Films | true | false |
| 23 | - | With or Without You | $1,742 | - | 1 | - | $1,742 | $1,742 | 1 | Gil Scrine Films | true | false |
| 24 | - | The Merchant of Venice 2009 Re-release | $1,729 | - | 3 | - | $576 | $1,729 | - | Arkles Entertainment | - | false |
| 25 | - | I Really Hate My Job 2009 Re-release | $1,628 | - | 2 | - | $814 | $1,628 | 1 | Icon Film Distribution | true | false |
