| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Terminator Salvation | $714,520 | - | 109 | - | $6,555 | $995,987 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Angels & Demons | $634,297 | -16.1% | 129 | -3 | $4,917 | $5,640,120 | 4 | Sony Pictures Releasing | false | false |
| 3 | 2 | Night at the Museum: Battle of the Smithsonian | $284,167 | -5.8% | 101 | - | $2,813 | $1,610,209 | 3 | Warner Bros. | false | false |
| 4 | 3 | Duplicity | $130,718 | +0.5% | 38 | - | $3,439 | $337,624 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Coco Before Chanel | $121,807 | +18.5% | 30 | - | $4,060 | $344,237 | 2 | RCV Film Distribution | false | false |
| 6 | 6 | Fighting | $85,054 | +2.4% | 38 | -1 | $2,238 | $493,302 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 8 | I Love You, Man | $80,303 | +7% | 29 | - | $2,769 | $193,366 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | 17 Again | $78,489 | +2.7% | 69 | -1 | $1,137 | $2,093,746 | 7 | RCV Film Distribution | false | false |
| 9 | 5 | Star Trek | $68,779 | -19.2% | 64 | -10 | $1,074 | $1,363,982 | 5 | Universal Pictures International (UPI) | false | false |
| 10 | 10 | The Reader | $49,641 | +19.1% | 35 | -1 | $1,418 | $1,704,936 | 10 | Benelux Film Distributors | false | false |
| 11 | 20 | Beverly Hills Chihuahua | $42,509 | +171.1% | 60 | - | $708 | $803,369 | 7 | Walt Disney Pictures | false | false |
| 12 | 18 | Monsters vs. Aliens | $37,772 | +79.8% | 104 | -5 | $363 | $2,086,870 | 10 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Slumdog Millionaire | $36,619 | +5% | 48 | - | $762 | $5,149,469 | 17 | Cinéart | false | false |
| 14 | - | Disgrace | $35,200 | - | 11 | - | $3,200 | $44,019 | 1 | A-Film Distribution | true | false |
| 15 | 19 | Coraline | $35,089 | +96.6% | 75 | -4 | $467 | $265,543 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 9 | X-Men Origins: Wolverine | $33,773 | -49.5% | 52 | -21 | $649 | $2,616,177 | 6 | Warner Bros. | false | false |
| 17 | 13 | Sunshine Cleaning | $30,423 | +19.7% | 22 | -3 | $1,382 | $281,775 | 4 | A-Film Distribution | false | false |
| 18 | 12 | He's Just Not That Into You | $28,502 | -12% | 26 | -13 | $1,096 | $1,747,003 | 8 | Paradiso Entertainment | false | false |
| 19 | 15 | The Brothers Bloom | $27,015 | +20.8% | 20 | - | $1,350 | $90,921 | 2 | A-Film Distribution | false | false |
| 20 | 14 | The Last Days of Emma Blank | $22,334 | -9.1% | 21 | -1 | $1,063 | $276,857 | 5 | A-Film Distribution | false | false |
