| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $5,250,380 | - | 422 | - | $12,441 | $5,250,380 | - | Warner Bros. | - | false |
| 2 | 1 | Terminator Salvation | $3,208,155 | -58% | 484 | -5 | $6,628 | $17,993,046 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | Night at the Museum: Battle of the Smithsonian | $1,781,470 | -53.8% | 506 | -3 | $3,520 | $28,135,154 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | Drag Me to Hell | $879,252 | -57.2% | 385 | -23 | $2,283 | $8,755,466 | 3 | Lionsgate Films | false | false |
| 5 | 4 | Angels & Demons | $846,017 | -50.6% | 384 | -70 | $2,203 | $26,825,265 | 5 | Sony Pictures Releasing | false | false |
| 6 | 5 | Star Trek | $666,188 | -51.1% | 374 | -49 | $1,781 | $33,397,866 | 6 | Paramount Pictures International | false | false |
| 7 | - | The Last House on the Left | $644,687 | - | 304 | - | $2,120 | $644,687 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | - | Looking for Eric | $602,075 | - | 239 | - | $2,519 | $602,075 | 1 | Entertainment Film Distributors | true | false |
| 9 | 6 | Last Chance Harvey | $433,908 | -57.6% | 309 | +7 | $1,404 | $2,274,231 | 2 | Momentum Pictures | false | false |
| 10 | 7 | Coraline | $265,727 | -55.1% | 368 | -24 | $722 | $11,486,068 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | - | Red Cliff | $251,994 | - | 189 | - | $1,333 | $251,994 | 1 | Entertainment Film Distributors | true | false |
| 12 | 8 | Hannah Montana: The Movie | $200,393 | -51.3% | 380 | -39 | $527 | $13,290,564 | 7 | Walt Disney Pictures | false | false |
| 13 | - | Doghouse | $92,855 | - | 99 | - | $937 | $92,855 | 1 | Vertigo Films | true | false |
| 14 | 12 | Anything for Her | $61,795 | -56.8% | 38 | -5 | $1,626 | $293,702 | 2 | - | false | false |
| 15 | - | The End of the Line | $54,079 | - | 5 | - | $10,815 | $54,079 | 1 | Periscoop Film | true | false |
| 16 | 11 | Obsessed | $39,531 | -80.6% | 64 | -67 | $617 | $808,860 | 3 | Sony Pictures Releasing | false | false |
| 17 | 10 | X-Men Origins: Wolverine | $35,226 | -83.3% | 95 | -113 | $370 | $26,714,027 | 7 | 20th Century Fox International | false | false |
| 18 | 9 | 12 Rounds | $22,059 | -90.6% | 74 | -217 | $298 | $1,169,053 | 3 | 20th Century Fox International | false | false |
| 19 | 14 | Synecdoche, New York | $19,456 | -62.8% | 14 | -14 | $1,389 | $766,215 | 5 | Revolver Entertainment | false | false |
| 20 | 15 | Monsters vs. Aliens | $19,115 | -62.4% | 78 | -32 | $245 | $34,731,668 | 11 | Paramount Pictures International | false | false |
| 21 | - | State of Play | $16,119 | - | 18 | - | $895 | $9,141,633 | 8 | Universal Pictures International (UPI) | false | false |
| 22 | 16 | In the Loop | $15,492 | -45.5% | 16 | -2 | $968 | $3,450,715 | 9 | Optimum Releasing | false | false |
| 23 | - | I Love You, Man | $14,154 | - | 16 | - | $884 | $6,795,337 | 9 | Paramount Pictures International | false | false |
| 24 | - | Ghosts of Girlfriends Past | $12,127 | - | 17 | - | $713 | $6,819,600 | 7 | Entertainment Film Distributors | false | false |
| 25 | 13 | Jonas Brothers: The 3D Concert Experience | $10,246 | -90.6% | 29 | -132 | $353 | $409,245 | 3 | Walt Disney Pictures | false | false |
| 26 | 18 | Sleep Furiously | $8,927 | -50.7% | 10 | - | $892 | $76,370 | 3 | New Wave Films | false | false |
| 27 | - | Fighting | $8,215 | - | 26 | - | $315 | $3,322,011 | 5 | Universal Pictures International (UPI) | false | false |
| 28 | - | Let the Right One In | $6,947 | - | 5 | - | $1,389 | $1,751,768 | 10 | Momentum Pictures | false | false |
| 29 | 21 | Chéri | $6,273 | -38.7% | 20 | +3 | $313 | $639,571 | 6 | Warner Bros. | false | false |
| 30 | - | 17 Again | $5,973 | - | 12 | - | $497 | $18,461,763 | 10 | Entertainment Film Distributors | false | false |
| 31 | - | Munde U.K. De | $5,802 | - | 3 | - | $1,934 | $295,905 | 6 | - | false | false |
| 32 | - | Under the Sea 3D | $5,544 | - | 1 | - | $5,544 | $338,828 | 18 | IMAX | false | false |
| 33 | - | Everlasting Moments | $4,917 | - | 5 | - | $983 | $78,876 | 4 | Icon Film Distribution | false | false |
| 34 | - | A Girl Cut in Two | $4,743 | - | 4 | - | $1,185 | $84,251 | 4 | Artificial Eye | false | false |
| 35 | - | Gran Torino | $4,342 | - | 7 | - | $620 | $13,671,067 | 17 | Warner Bros. | false | false |
| 36 | - | Fermat's Room 2009 Re-release | $4,014 | - | 5 | - | $802 | $24,238 | 3 | Revolver Entertainment | false | false |
| 37 | - | New Town Killers | $3,280 | - | 8 | - | $410 | $3,280 | 1 | N/A | true | false |
| 38 | 23 | The Boat That Rocked | $3,143 | -58.3% | 4 | - | $785 | $10,084,644 | 11 | Universal Pictures International (UPI) | false | false |
| 39 | 20 | Sugar | $2,873 | -77.3% | 4 | +3 | $718 | $21,794 | 2 | Axiom Films | false | false |
| 40 | 27 | Shadows in the Sun | $2,205 | -0.6% | 1 | -1 | $2,205 | $6,367 | 2 | Artificial Eye | false | false |
| 41 | 19 | Is Anybody There? | $1,743 | -88.5% | 12 | -10 | $145 | $709,841 | 7 | Optimum Releasing | false | false |
| 42 | - | Soi Cowboy | $1,575 | - | 1 | - | $1,575 | $1,575 | 1 | N/A | true | false |
| 43 | 26 | The Damned United | $1,175 | -51.8% | 3 | -2 | $391 | $3,582,592 | 12 | Sony Pictures Releasing | false | false |
| 44 | 30 | The Hide | $891 | - | 1 | - | $891 | $2,313 | 2 | ICA Films | false | false |
| 45 | 17 | Tormented | $707 | -97.2% | 10 | -49 | $70 | $1,147,307 | 4 | Warner Bros. | false | false |
| 46 | 29 | Fifty Dead Men Walking | $590 | -42.1% | 3 | -1 | $196 | $636,507 | 10 | - | false | false |
| 47 | - | The Age of Stupid | $531 | - | 3 | - | $177 | $310,829 | 13 | Periscoop Film | false | false |
| 48 | 25 | Awaydays | $441 | -88.6% | 2 | -8 | $220 | $128,465 | 4 | Optimum Releasing | false | false |
