| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $32,713 | - | 3 | - | $10,904 | $32,713 | 1 | - | true | false |
| 2 | 1 | Terminator Salvation | $25,281 | -60.9% | 6 | - | $4,213 | $118,991 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | The Tale of Despereaux | $13,534 | -17.7% | 7 | - | $1,933 | $61,974 | 3 | - | false | false |
| 4 | - | Drag Me to Hell | $13,070 | - | 2 | - | $6,535 | $13,070 | 1 | ACME | true | false |
| 5 | 3 | Angels & Demons | $12,167 | -18.1% | 7 | - | $1,738 | $271,403 | 5 | Sony Pictures Releasing | false | false |
| 6 | 4 | Night at the Museum: Battle of the Smithsonian | $8,351 | -31.4% | 4 | - | $2,087 | $96,408 | 4 | - | false | false |
| 7 | 5 | 17 Again | $3,656 | -53.4% | 3 | - | $1,218 | $85,568 | 6 | - | false | false |
| 8 | 6 | The Great Buck Howard | $2,854 | -31.4% | 1 | - | $2,854 | $9,952 | 2 | ACME | false | false |
| 9 | 9 | Knowing | $2,758 | +13.2% | 2 | - | $1,379 | $78,409 | 10 | ACME | false | false |
| 10 | 7 | The Boat That Rocked | $2,636 | -21% | 3 | - | $878 | $54,660 | 7 | - | false | false |
| 11 | 10 | I Love You, Man | $2,073 | -1.1% | 3 | - | $691 | $60,325 | 8 | - | false | false |
| 12 | 13 | Hannah Montana: The Movie | $911 | -25.1% | 2 | - | $455 | $19,625 | 5 | - | false | false |
| 13 | 8 | Observe and Report | $909 | -63% | 2 | - | $454 | $13,340 | 3 | - | false | false |
| 14 | 12 | X-Men Origins: Wolverine | $718 | -44.5% | 4 | - | $179 | $67,435 | 7 | - | false | false |
| 15 | 15 | Newsmakers | $694 | -0.9% | 1 | - | $694 | $12,151 | 5 | N/A | false | false |
