| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $725,920 | - | 64 | - | $11,342 | $784,443 | 1 | Warner Bros. | true | false |
| 2 | 2 | Angels & Demons | $474,719 | -25.2% | 129 | - | $3,679 | $6,305,389 | 5 | Sony Pictures Releasing | false | false |
| 3 | 1 | Terminator Salvation | $338,945 | -52.6% | 109 | - | $3,109 | $1,532,945 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | Night at the Museum: Battle of the Smithsonian | $206,211 | -27.4% | 101 | - | $2,041 | $1,881,107 | 4 | Warner Bros. | false | false |
| 5 | 5 | Coco Before Chanel | $87,343 | -28.3% | 31 | +1 | $2,817 | $493,706 | 3 | RCV Film Distribution | false | false |
| 6 | 4 | Duplicity | $81,048 | -38% | 38 | - | $2,132 | $464,519 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | - | The Last House on the Left | $72,190 | - | 20 | - | $3,609 | $106,244 | 1 | Universal Pictures International (UPI) | true | false |
| 8 | 8 | 17 Again | $59,865 | -23.7% | 67 | -2 | $893 | $2,183,088 | 8 | RCV Film Distribution | false | false |
| 9 | 11 | Beverly Hills Chihuahua | $48,796 | +14.8% | 60 | - | $813 | $866,899 | 8 | Walt Disney Pictures | false | false |
| 10 | 7 | I Love You, Man | $45,324 | -43.6% | 29 | - | $1,562 | $268,728 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Star Trek | $42,310 | -38.5% | 43 | -21 | $983 | $1,446,265 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 6 | Fighting | $42,285 | -50.3% | 32 | -6 | $1,321 | $567,009 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 10 | The Reader | $38,045 | -23.4% | 35 | - | $1,087 | $1,774,802 | 11 | Benelux Film Distributors | false | false |
| 14 | 12 | Monsters vs. Aliens | $31,988 | -15.3% | 89 | -15 | $359 | $2,137,039 | 11 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | Disgrace | $29,564 | -16% | 11 | - | $2,687 | $93,884 | 2 | A-Film Distribution | false | false |
| 16 | 15 | Coraline | $26,447 | -24.6% | 69 | -6 | $383 | $301,992 | 5 | Universal Pictures International (UPI) | false | false |
| 17 | 17 | Sunshine Cleaning | $23,352 | -23.2% | 19 | -3 | $1,229 | $316,602 | 5 | A-Film Distribution | false | false |
| 18 | 13 | Slumdog Millionaire | $22,019 | -39.9% | 40 | -8 | $550 | $5,212,580 | 18 | Cinéart | false | false |
| 19 | 20 | The Last Days of Emma Blank | $19,376 | -13.2% | 20 | -1 | $968 | $309,112 | 6 | A-Film Distribution | false | false |
| 20 | - | The Young Victoria | $14,458 | - | 21 | - | $688 | $152,956 | 4 | Paradiso Entertainment | false | false |
