| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $50,740 | -33.3% | 8 | - | $6,342 | $146,957 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | Terminator Salvation | $23,393 | -53.8% | 11 | - | $2,126 | $185,675 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | My Bloody Valentine | $11,333 | -41.7% | 2 | - | $5,666 | $92,564 | 15 | - | false | false |
| 4 | 5 | Angels & Demons | $10,225 | -32.7% | 8 | +1 | $1,278 | $222,251 | 6 | Sony Pictures Releasing | false | false |
| 5 | 4 | Night at the Museum: Battle of the Smithsonian | $8,127 | -49.8% | 6 | - | $1,354 | $144,078 | 5 | 20th Century Fox International | false | false |
| 6 | 6 | Watchmen | $5,500 | -36.9% | 6 | - | $916 | $17,303 | 2 | United International Pictures | false | false |
| 7 | - | Death Sentence | $4,480 | - | 2 | - | $2,240 | $4,480 | 1 | - | true | false |
| 8 | 8 | He's Just Not That Into You | $919 | -71.3% | 1 | - | $919 | $16,740 | 9 | PlayArte Pictures | false | false |
