| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Night at the Museum: Battle of the Smithsonian | $1,875,307 | -42.2% | 811 | -1 | $2,312 | $6,684,680 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Up | $1,673,075 | -33.4% | 785 | -14 | $2,131 | $10,696,873 | 3 | Walt Disney Pictures | false | false |
| 3 | - | The Proposal | $1,410,570 | - | 436 | - | $3,235 | $1,513,054 | 1 | Walt Disney Pictures | true | false |
| 4 | - | 17 Again | $631,003 | - | 310 | - | $2,035 | $631,003 | 1 | Gussi Films | true | false |
| 5 | 4 | Angels & Demons | $405,094 | -41.9% | 448 | -190 | $904 | $12,749,994 | 6 | Sony Pictures Releasing | false | false |
| 6 | 3 | X-Men Origins: Wolverine | $401,361 | -48.5% | 395 | -72 | $1,016 | $9,756,180 | 8 | 20th Century Fox International | false | false |
| 7 | 5 | Star Trek | $377,386 | -35.2% | 380 | -65 | $993 | $2,997,840 | 7 | Paramount Pictures International | false | false |
| 8 | 6 | State of Play | $75,705 | -61.6% | 90 | -151 | $841 | $1,376,826 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Hannah Montana: The Movie | $57,795 | -29.3% | 126 | -78 | $458 | $2,304,158 | 5 | Walt Disney Pictures | false | false |
| 10 | 13 | The Last House on the Left | $52,496 | +97.8% | 95 | +51 | $552 | $340,709 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 7 | Zack and Miri Make a Porno | $49,580 | -63.1% | 113 | -54 | $438 | $310,752 | 3 | Gussi Films | false | false |
| 12 | 11 | Push | $36,020 | -12.4% | 52 | +18 | $692 | $684,680 | 14 | N/A | false | false |
| 13 | 10 | Ghosts of Girlfriends Past | $27,901 | -51.7% | 45 | -32 | $620 | $2,639,758 | 6 | Warner Bros. | false | false |
| 14 | 9 | While She Was Out | $25,761 | -68.1% | 63 | -6 | $408 | $165,113 | 2 | Gussi Films | false | false |
| 15 | - | 3:19 | $20,614 | - | 38 | - | $542 | $20,614 | 110 | N/A | false | false |
| 16 | - | I'm Gonna Explode | $18,429 | - | 40 | - | $460 | $18,525 | 110 | Videocine | false | false |
| 17 | 12 | Sin Nombre | $12,412 | -56.8% | 38 | -32 | $326 | $570,986 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 22 | Rachel Getting Married | $4,776 | +70.2% | 6 | +1 | $796 | $135,521 | 14 | Sony Pictures Releasing | false | false |
| 19 | 15 | The Band's Visit | $4,008 | -63.6% | 5 | -6 | $801 | $42,497 | 3 | N/A | false | false |
| 20 | 19 | Three Monkeys | $3,410 | -48.5% | 4 | - | $852 | $12,690 | 2 | N/A | false | false |
| 21 | 14 | Then She Found Me | $3,088 | -77.9% | 15 | -14 | $205 | $135,329 | 6 | Videocine | false | false |
| 22 | 20 | Earth | $1,901 | -58.4% | 15 | -4 | $126 | $934,851 | 6 | Walt Disney Pictures | false | false |
| 23 | 24 | Mister Lonely | $1,032 | -45% | 2 | - | $516 | $20,759 | 4 | N/A | false | false |
| 24 | 17 | The Haunting in Connecticut | $746 | -90.6% | 3 | -16 | $248 | $2,705,122 | 10 | Gussi Films | false | false |
| 25 | 27 | Personal Effects | $334 | +3.7% | 2 | +1 | $167 | $72,730 | 4 | Gussi Films | false | false |
| 26 | 28 | Boogeyman 2 | $78 | -74.3% | 2 | +1 | $39 | $74,625 | 7 | Gussi Films | false | false |
