| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $54,143 | - | 5 | - | $10,828 | $54,143 | 1 | - | true | false |
| 2 | 1 | The Hangover | $17,585 | <0.1% | 3 | - | $5,861 | $101,337 | 3 | - | false | false |
| 3 | 3 | Angels & Demons | $5,386 | -3.5% | 7 | - | $769 | $290,041 | 7 | Sony Pictures Releasing | false | false |
| 4 | 2 | Terminator Salvation | $4,991 | -44.2% | 6 | - | $831 | $149,854 | 4 | Sony Pictures Releasing | false | false |
| 5 | 4 | Ultimate Heist | $4,281 | -13.7% | 1 | - | $4,281 | $11,883 | 2 | ACME | false | false |
| 6 | 8 | Night at the Museum: Battle of the Smithsonian | $3,888 | +32.9% | 4 | - | $972 | $110,570 | 6 | - | false | false |
| 7 | 5 | The Tale of Despereaux | $3,880 | -20.4% | 7 | - | $554 | $78,963 | 5 | - | false | false |
| 8 | 7 | Drag Me to Hell | $3,642 | -1.9% | 2 | - | $1,821 | $33,039 | 3 | ACME | false | false |
| 9 | 6 | The Uninvited | $3,291 | -19.5% | 3 | - | $1,097 | $9,884 | 2 | - | false | false |
| 10 | 9 | 17 Again | $2,906 | +10.4% | 3 | - | $968 | $95,570 | 8 | - | false | false |
| 11 | 11 | Knowing | $1,928 | +21.2% | 2 | - | $964 | $83,546 | 12 | ACME | false | false |
| 12 | 10 | The Great Buck Howard | $1,704 | +3.5% | 1 | - | $1,704 | $15,538 | 4 | ACME | false | false |
| 13 | 12 | The Boat That Rocked | $1,557 | +5% | 3 | - | $519 | $60,077 | 9 | - | false | false |
| 14 | 13 | I Love You, Man | $1,442 | +91.5% | 3 | - | $480 | $64,090 | 10 | - | false | false |
