| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $1,080,559 | - | 108 | - | $10,005 | $1,478,351 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 2 | The Proposal | $424,893 | -17.9% | 84 | - | $5,058 | $1,197,183 | 2 | Walt Disney Pictures | false | false |
| 3 | 1 | The Hangover | $395,486 | -27.3% | 67 | - | $5,902 | $2,099,096 | 3 | Warner Bros. | false | false |
| 4 | 3 | Angels & Demons | $160,443 | -54.3% | 123 | -2 | $1,304 | $7,096,841 | 7 | Sony Pictures Releasing | false | false |
| 5 | 4 | Terminator Salvation | $92,006 | -54.1% | 86 | -16 | $1,069 | $1,979,447 | 4 | Sony Pictures Releasing | false | false |
| 6 | 5 | Night at the Museum: Battle of the Smithsonian | $84,042 | -41.1% | 99 | -3 | $848 | $2,184,834 | 6 | Warner Bros. | false | false |
| 7 | 6 | State of Play | $61,967 | -44.7% | 48 | +1 | $1,290 | $238,546 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Coco Before Chanel | $37,263 | -39% | 30 | -1 | $1,242 | $670,574 | 5 | RCV Film Distribution | false | false |
| 9 | 11 | 17 Again | $28,117 | -15.6% | 56 | -10 | $502 | $2,276,731 | 10 | RCV Film Distribution | false | false |
| 10 | 8 | The Last House on the Left | $25,509 | -38.5% | 19 | -1 | $1,342 | $218,682 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Beverly Hills Chihuahua | $23,051 | -35% | 60 | - | $384 | $944,354 | 10 | Walt Disney Pictures | false | false |
| 12 | 12 | Monsters vs. Aliens | $16,654 | -38.8% | 75 | -20 | $222 | $2,201,054 | 13 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Duplicity | $16,491 | -57.3% | 27 | -6 | $610 | $557,271 | 5 | Universal Pictures International (UPI) | false | false |
| 14 | - | Chéri | $16,081 | - | 19 | - | $846 | $20,974 | 1 | Benelux Film Distributors | true | false |
| 15 | 15 | Disgrace | $14,521 | -33.1% | 11 | - | $1,320 | $153,422 | 4 | A-Film Distribution | false | false |
| 16 | 14 | The Reader | $14,468 | -41.3% | 34 | -1 | $425 | $1,857,654 | 13 | Benelux Film Distributors | false | false |
| 17 | 16 | Coraline | $11,971 | -36.9% | 53 | -11 | $225 | $344,879 | 7 | Universal Pictures International (UPI) | false | false |
| 18 | 20 | Slumdog Millionaire | $11,894 | -23.4% | 38 | +2 | $313 | $5,282,849 | 20 | Cinéart | false | false |
| 19 | 13 | Star Trek | $10,597 | -57.2% | 11 | -10 | $963 | $1,509,031 | 8 | Universal Pictures International (UPI) | false | false |
| 20 | 19 | The Girl on the Train | $9,738 | -41.9% | 11 | - | $885 | $36,940 | 2 | Benelux Film Distributors | false | false |
