| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $715,732 | - | 97 | - | $7,378 | $715,732 | 1 | United International Pictures | true | false |
| 2 | 1 | The Hangover | $175,929 | -21.8% | 55 | - | $3,198 | $519,696 | 2 | NuMetro Distribution | false | false |
| 3 | 2 | Night at the Museum: Battle of the Smithsonian | $113,930 | +24.4% | 78 | -3 | $1,460 | $1,305,613 | 6 | NuMetro Distribution | false | false |
| 4 | 3 | Terminator Salvation | $62,274 | -13.2% | 79 | - | $788 | $760,116 | 4 | Ster-Kinekor Pictures | false | false |
| 5 | 4 | Ghosts of Girlfriends Past | $57,383 | +31.4% | 44 | -3 | $1,304 | $857,277 | 7 | NuMetro Distribution | false | false |
| 6 | 6 | Drag Me to Hell | $46,028 | +15.2% | 40 | - | $1,150 | $238,259 | 3 | NuMetro Distribution | false | false |
| 7 | 5 | Obsessed | $44,104 | +9.7% | 24 | - | $1,837 | $108,297 | 2 | Ster-Kinekor Pictures | false | false |
| 8 | 8 | Duplicity | $37,758 | +2.9% | 43 | - | $878 | $538,578 | 5 | United International Pictures | false | false |
| 9 | 7 | State of Play | $36,661 | -4% | 31 | - | $1,182 | $234,401 | 3 | United International Pictures | false | false |
| 10 | 9 | Angels & Demons | $23,189 | -21.8% | 34 | -23 | $682 | $1,033,390 | 7 | Ster-Kinekor Pictures | false | false |
| 11 | - | The Young Victoria | $22,182 | - | 10 | - | $2,218 | $22,182 | 1 | NuMetro Distribution | true | false |
| 12 | - | New York | $19,162 | - | 5 | - | $3,832 | $19,162 | 1 | NuMetro Distribution | true | false |
| 13 | 10 | 17 Again | $18,963 | +35.5% | 26 | -7 | $729 | $1,276,156 | 11 | NuMetro Distribution | false | false |
| 14 | 11 | Sunshine Cleaning | $9,234 | -8.8% | 10 | - | $923 | $56,823 | 3 | United International Pictures | false | false |
| 15 | 12 | Hannah Montana: The Movie | $7,773 | -13.7% | 16 | -9 | $485 | $740,321 | 9 | Ster-Kinekor Pictures | false | false |
| 16 | - | Welcome to the Sticks | $7,738 | - | 4 | - | $1,934 | $7,761 | 1 | Ster-Kinekor Pictures | true | false |
| 17 | 19 | White Wedding | $7,051 | +102.2% | 10 | -2 | $705 | $611,611 | 9 | Ster-Kinekor Pictures | false | false |
| 18 | 16 | The Burning Plain | $5,846 | -10.3% | 8 | -2 | $730 | $63,308 | 4 | United International Pictures | false | false |
| 19 | 14 | Coraline | $5,605 | -27.4% | 6 | -3 | $934 | $206,091 | 8 | United International Pictures | false | false |
| 20 | 13 | X-Men Origins: Wolverine | $4,866 | -41.2% | 12 | -11 | $405 | $1,322,059 | 9 | NuMetro Distribution | false | false |
| 21 | 15 | Star Trek | $3,437 | -50.5% | 11 | -3 | $312 | $381,276 | 8 | United International Pictures | false | false |
| 22 | 18 | Slumdog Millionaire | $2,693 | -29.3% | 9 | -6 | $299 | $1,245,660 | 17 | Ster-Kinekor Pictures | false | false |
| 23 | 17 | The Last House on the Left | $2,364 | -53% | 10 | -5 | $236 | $124,561 | 6 | United International Pictures | false | false |
| 24 | 21 | The Reader | $2,101 | -28.1% | 4 | -3 | $525 | $337,981 | 14 | Ster-Kinekor Pictures | false | false |
