| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $11,492,142 | - | 510 | - | $22,533 | $14,999,929 | 1 | Warner Bros. | true | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $2,522,442 | -41.4% | 387 | -38 | $6,517 | $19,164,486 | 3 | 20th Century Fox International | false | false |
| 3 | 1 | Brüno | $1,638,370 | -64.1% | 335 | +1 | $4,890 | $9,008,788 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Transformers: Revenge of the Fallen | $1,356,190 | -53.1% | 380 | -77 | $3,568 | $29,541,283 | 4 | Paramount Pictures International | false | false |
| 5 | 4 | Hannah Montana: The Movie | $839,966 | -41.1% | 225 | -44 | $3,733 | $7,094,491 | 4 | Walt Disney Pictures | false | false |
| 6 | 5 | The Hangover | $720,321 | -36.2% | 193 | -21 | $3,732 | $14,637,379 | 6 | Warner Bros. | false | false |
| 7 | - | My Life in Ruins | $632,914 | - | 169 | - | $3,745 | $653,226 | 1 | 20th Century Fox International | true | false |
| 8 | 6 | The Proposal | $575,018 | -49% | 193 | -74 | $2,979 | $11,830,101 | 5 | Walt Disney Pictures | false | false |
| 9 | 8 | Coco Before Chanel | $154,280 | -32.4% | 26 | - | $5,933 | $1,346,027 | 4 | Roadshow Films | false | false |
| 10 | 7 | Year One | $67,351 | -75.3% | 71 | -94 | $948 | $4,325,447 | 5 | Sony Pictures Releasing | false | false |
| 11 | 11 | Disgrace | $56,559 | -36% | 35 | +2 | $1,615 | $768,219 | 5 | Icon Film Distribution | false | false |
| 12 | 9 | Night at the Museum: Battle of the Smithsonian | $49,963 | -71.7% | 71 | -47 | $703 | $13,746,000 | 9 | 20th Century Fox International | false | false |
| 13 | 15 | Samson & Delilah | $40,301 | -20.2% | 25 | -7 | $1,612 | $2,196,266 | 11 | Paramount Pictures International | false | false |
| 14 | 16 | Last Ride | $31,953 | -31.4% | 17 | +1 | $1,879 | $203,907 | 3 | Madman Entertainment | false | false |
| 15 | - | Red Cliff | $30,574 | - | 47 | - | $650 | $45,058 | - | Icon Film Distribution | - | false |
| 16 | 13 | State of Play | $30,307 | -54.8% | 46 | -15 | $658 | $5,558,305 | 8 | Universal Pictures International (UPI) | false | false |
| 17 | 19 | The Fox and the Child | $25,951 | -18.9% | 9 | - | $2,883 | $85,331 | 2 | Hopscotch Films | false | false |
| 18 | - | My Friends, My Love 2009 Re-release | $24,006 | - | 9 | - | $2,667 | $28,348 | 1 | Hopscotch Films | true | false |
| 19 | 10 | Terminator Salvation | $23,319 | -77% | 32 | -54 | $728 | $11,960,230 | 7 | Sony Pictures Releasing | false | false |
| 20 | - | My Year Without Sex | $21,442 | - | 18 | - | $1,191 | $795,162 | 9 | Paramount Pictures International | false | false |
| 21 | - | Every Little Step | $11,615 | - | 4 | - | $2,903 | $64,545 | 3 | Sony Pictures Releasing | false | false |
| 22 | 14 | Angels & Demons | $11,251 | -79.7% | 23 | -24 | $489 | $14,065,391 | 10 | Sony Pictures Releasing | false | false |
| 23 | - | The Escapist | $9,849 | - | 4 | - | $2,462 | $9,849 | 1 | Rialto Distribution | true | false |
| 24 | - | Dark Frontier | $9,152 | - | 8 | - | $1,144 | $9,152 | 1 | N/A | true | false |
