| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $1,824,783 | - | 95 | - | $19,208 | $1,826,569 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $1,040,125 | -0.7% | 170 | +12 | $6,118 | $5,375,230 | 4 | 20th Century Fox International | false | false |
| 3 | 2 | The Taking of Pelham 123 | $212,101 | -20.1% | 45 | - | $4,713 | $561,582 | 2 | Sony Pictures Releasing | false | false |
| 4 | 3 | Transformers: Revenge of the Fallen | $132,679 | -35.1% | 119 | +2 | $1,114 | $2,294,714 | 5 | Paramount Pictures International | false | false |
| 5 | 4 | The Proposal | $109,870 | -20.9% | 79 | -2 | $1,390 | $707,603 | 4 | Walt Disney Pictures | false | false |
| 6 | 5 | Up | $73,013 | -13% | 101 | -28 | $722 | $3,370,436 | 7 | Walt Disney Pictures | false | false |
| 7 | 6 | 100% lucha, el amo de los clones | $61,458 | -7.6% | 67 | - | $917 | $170,388 | 2 | Primer Plano Film Group | false | false |
| 8 | 7 | I've Loved You So Long | $44,274 | -24.7% | 19 | - | $2,330 | $119,334 | 2 | Alfa Films | false | false |
| 9 | 8 | Solstice | $35,034 | -33% | 26 | - | $1,347 | $208,358 | 3 | Distribution Company | false | false |
| 10 | - | Days and Clouds | $33,903 | - | 9 | - | $3,767 | $33,903 | 1 | Impacto Cine | true | false |
| 11 | 9 | State of Play | $10,385 | -41.6% | 12 | -7 | $865 | $504,673 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | - | Home | $9,254 | - | 5 | - | $1,850 | $9,254 | 1 | Primer Plano Film Group | true | false |
| 13 | 12 | Last Chance Harvey | $8,508 | -45.2% | 9 | -13 | $945 | $457,207 | 8 | Distribution Company | false | false |
| 14 | 11 | A Christmas Tale | $6,634 | -59.9% | 5 | -6 | $1,326 | $77,150 | 4 | Pachamama Cine | false | false |
| 15 | 13 | Pride and Glory | $6,619 | -37.7% | 7 | -8 | $945 | $128,679 | 5 | Distribution Company | false | false |
| 16 | - | Killshot | $5,825 | - | 9 | - | $647 | $59,745 | - | Distribution Company | - | false |
| 17 | 17 | Katyn | $4,934 | -23.8% | 3 | - | $1,644 | $13,726 | 2 | N/A | false | false |
| 18 | 15 | Felicitas | $4,333 | -43.1% | 10 | -6 | $433 | $432,133 | 7 | Pachamama Cine | false | false |
| 19 | 20 | The Secrets | $2,883 | -41% | 4 | -1 | $720 | $9,179 | 2 | Distribution Company | false | false |
| 20 | 16 | Terminator Salvation | $2,745 | -62.2% | 8 | -18 | $343 | $1,971,106 | 8 | Sony Pictures Releasing | false | false |
| 21 | 19 | The Visitor | $2,425 | -52.1% | 3 | -10 | $808 | $111,311 | 6 | Impacto Cine | false | false |
| 22 | 10 | Penelope | $2,204 | -87.6% | 7 | -15 | $314 | $28,419 | 2 | Distribution Company | false | false |
| 23 | 18 | The Unborn | $2,027 | -62.3% | 9 | -10 | $225 | $775,619 | 10 | Universal Pictures International (UPI) | false | false |
| 24 | 22 | Ghosts of Girlfriends Past | $1,689 | -51.5% | 4 | -5 | $422 | $458,639 | 7 | Distribution Company | false | false |
| 25 | 25 | Night at the Museum: Battle of the Smithsonian | $1,577 | -12.1% | 9 | +3 | $175 | $2,555,521 | 10 | 20th Century Fox International | false | false |
| 26 | 31 | All the Lonely People | $764 | +218.3% | 2 | +1 | $382 | $15,657 | 6 | Primer Plano Film Group | false | false |
| 27 | 21 | Happy-Go-Lucky | $757 | -79.7% | 3 | -5 | $252 | $128,811 | 6 | N/A | false | false |
| 28 | 26 | Inspector Bellamy | $669 | -26.4% | 2 | -2 | $334 | $139,640 | 8 | Alfa Films | false | false |
| 29 | 24 | Che: Part Two | $659 | -78.7% | 2 | -4 | $329 | $51,073 | 6 | Alfa Films | false | false |
| 30 | 32 | The Reader | $216 | +24.1% | 1 | - | $216 | $575,446 | 12 | Pachamama Cine | false | false |
| 31 | 29 | 17 Again | $124 | -51.8% | 1 | - | $124 | $421,582 | 12 | Distribution Company | false | false |
| 32 | 33 | Lorna's Silence | $90 | -43% | 1 | - | $90 | $91,367 | 11 | Distribution Company | false | false |
| 33 | 37 | Race to Witch Mountain | $13 | +62.5% | 1 | - | $13 | $972,895 | 16 | Walt Disney Pictures | false | false |
| 34 | 35 | The Edge of Heaven | $5 | -88.1% | 1 | - | $5 | $155,500 | 19 | Alfa Films | false | false |
