| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $5,278,096 | -54.1% | 510 | - | $10,349 | $24,208,243 | 2 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $1,676,625 | -33.5% | 366 | -21 | $4,580 | $22,454,522 | 4 | 20th Century Fox International | false | false |
| 3 | 4 | Transformers: Revenge of the Fallen | $944,650 | -30.3% | 304 | -76 | $3,107 | $31,608,506 | 5 | Paramount Pictures International | false | false |
| 4 | - | Drag Me to Hell | $859,818 | - | 139 | - | $6,185 | $867,667 | 1 | Roadshow Films | true | false |
| 5 | 3 | Brüno | $827,006 | -49.5% | 265 | -70 | $3,120 | $10,586,067 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | 6 | The Hangover | $695,440 | -3.5% | 197 | +4 | $3,530 | $15,916,708 | 7 | Warner Bros. | false | false |
| 7 | 5 | Hannah Montana: The Movie | $525,734 | -37.4% | 193 | -32 | $2,724 | $8,239,435 | 5 | Walt Disney Pictures | false | false |
| 8 | 7 | My Life in Ruins | $490,840 | -22.4% | 169 | - | $2,904 | $1,475,541 | 2 | 20th Century Fox International | false | false |
| 9 | 8 | The Proposal | $482,864 | -16% | 173 | -20 | $2,791 | $12,826,045 | 6 | Walt Disney Pictures | false | false |
| 10 | - | Chéri | $243,098 | - | 53 | - | $4,586 | $258,959 | 1 | Icon Film Distribution | true | false |
| 11 | - | Red Cliff | $209,140 | - | 52 | - | $4,021 | $255,028 | 1 | Icon Film Distribution | true | false |
| 12 | 9 | Coco Before Chanel | $127,998 | -17% | 26 | - | $4,923 | $1,572,405 | 5 | Roadshow Films | false | false |
| 13 | 13 | Samson & Delilah | $46,714 | +15.9% | 30 | +5 | $1,557 | $2,313,410 | 12 | Paramount Pictures International | false | false |
| 14 | 11 | Disgrace | $40,364 | -28.6% | 29 | -6 | $1,391 | $850,392 | 6 | Icon Film Distribution | false | false |
| 15 | 10 | Year One | $33,932 | -49.6% | 40 | -31 | $848 | $4,471,739 | 6 | Sony Pictures Releasing | false | false |
| 16 | 16 | State of Play | $28,789 | -5% | 33 | -13 | $872 | $5,702,156 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | - | The Limits of Control | $23,683 | - | 5 | - | $4,736 | $28,767 | 1 | Universal Pictures International (UPI) | true | false |
| 18 | 14 | Last Ride | $21,038 | -34.2% | 17 | - | $1,237 | $244,165 | 4 | Madman Entertainment | false | false |
| 19 | - | Wake in Fright | $21,034 | - | 7 | - | $3,004 | $167,770 | 5 | Madman Entertainment | false | false |
| 20 | 12 | Night at the Museum: Battle of the Smithsonian | $17,408 | -65.2% | 34 | -37 | $512 | $14,037,398 | 10 | 20th Century Fox International | false | false |
| 21 | - | Cedar Boys | $13,143 | - | 32 | - | $410 | $13,143 | - | Hoyts Distribution | - | false |
| 22 | 21 | Every Little Step | $8,959 | -22.9% | 4 | - | $2,239 | $79,794 | 4 | Sony Pictures Releasing | false | false |
