| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $497,983 | -67.9% | 93 | - | $5,354 | $2,867,323 | 2 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $128,711 | -76.6% | 72 | -16 | $1,787 | $3,267,561 | 4 | 20th Century Fox International | false | false |
| 3 | 3 | Transformers: Revenge of the Fallen | $128,470 | -60% | 85 | -3 | $1,511 | $4,950,805 | 5 | Paramount Pictures International | false | false |
| 4 | 4 | Brüno | $126,224 | -48.5% | 50 | - | $2,524 | $1,299,341 | 3 | United International Pictures | false | false |
| 5 | - | Drag Me to Hell | $89,419 | - | 34 | - | $2,629 | $89,419 | 1 | Roadshow Films | true | false |
| 6 | 6 | The Hangover | $68,598 | -5.5% | 37 | -1 | $1,854 | $1,789,715 | 7 | Warner Bros. | false | false |
| 7 | 7 | The Proposal | $57,874 | -19.7% | 40 | - | $1,446 | $1,419,838 | 6 | Walt Disney Pictures | false | false |
| 8 | 5 | Hannah Montana: The Movie | $44,504 | -77.8% | 68 | -12 | $654 | $1,185,916 | 5 | Walt Disney Pictures | false | false |
| 9 | 8 | My Life in Ruins | $41,204 | -22.7% | 25 | - | $1,648 | $120,792 | 2 | 20th Century Fox International | false | false |
| 10 | - | Stone of Destiny | $31,947 | - | 27 | - | $1,183 | $31,947 | 1 | Rialto Distribution | true | false |
| 11 | 10 | The Sicilian Girl | $10,928 | -16.3% | 12 | - | $910 | $49,665 | 3 | Vendetta Films | false | false |
| 12 | 11 | Easy Virtue | $9,456 | -26% | 26 | +2 | $363 | $566,792 | 9 | Hopscotch Films | false | false |
| 13 | 9 | Phèdre | $9,393 | -65% | 5 | -11 | $1,878 | $42,188 | 2 | Rialto Distribution | false | false |
| 14 | 14 | Bride Flight | $9,082 | -8.7% | 27 | +5 | $336 | $121,769 | 5 | Hopscotch Films | false | false |
| 15 | 12 | I've Loved You So Long | $8,224 | -27.1% | 9 | -2 | $913 | $295,396 | 11 | Palace Films | false | false |
| 16 | 15 | A Bunch of Amateurs | $6,469 | -4.8% | 18 | -12 | $359 | $162,575 | 115 | Rialto Distribution | false | false |
| 17 | 20 | The Reader | $5,368 | +77.8% | 16 | +3 | $335 | $851,913 | 16 | Roadshow Films | false | false |
| 18 | 17 | Gomorrah | $3,362 | -19.6% | 4 | -1 | $840 | $54,244 | 6 | Madman Entertainment | false | false |
| 19 | 19 | Terminator Salvation | $3,010 | -9% | 6 | -4 | $501 | $1,661,065 | 8 | Sony Pictures Releasing | false | false |
| 20 | 18 | Angels & Demons | $2,757 | -33.9% | 9 | -2 | $306 | $1,971,833 | 11 | Sony Pictures Releasing | false | false |
