| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Ice Age: Dawn of the Dinosaurs | $1,024,747 | -0.8% | 92 | -1 | $11,138 | $8,108,849 | 4 | 20th Century Fox International | false | false |
| 2 | 1 | Harry Potter and the Half-Blood Prince | $987,627 | -26.3% | 82 | -38 | $12,044 | $4,257,267 | 2 | Warner Bros. | false | false |
| 3 | - | 17 Again | $164,548 | - | 20 | - | $8,227 | $197,140 | 1 | N/A | true | false |
| 4 | - | Transporter 3 | $136,902 | - | 23 | - | $5,952 | $181,279 | 1 | N/A | true | false |
| 5 | 3 | Transformers: Revenge of the Fallen | $129,105 | -43.1% | 27 | -31 | $4,781 | $3,891,148 | 5 | United International Pictures | false | false |
| 6 | - | I Love You, Man | $117,993 | - | 31 | - | $3,806 | $154,277 | 1 | United International Pictures | true | false |
| 7 | 4 | Up | $100,895 | -41.8% | 45 | -11 | $2,242 | $7,091,501 | 8 | Walt Disney Pictures | false | false |
| 8 | - | El ratón Pérez 2 | $68,117 | - | 30 | - | $2,270 | $77,763 | 1 | Walt Disney Pictures | true | false |
| 9 | 5 | The Last House on the Left | $44,398 | -49% | 24 | -8 | $1,849 | $454,352 | 3 | United International Pictures | false | false |
| 10 | 6 | Push | $36,935 | -31.3% | 17 | -1 | $2,172 | $287,873 | 16 | N/A | false | false |
| 11 | 8 | The Other Boleyn Girl | $20,362 | -18.3% | 5 | -1 | $4,072 | $139,184 | 3 | N/A | false | false |
| 12 | 9 | The Wrestler | $16,761 | -12.1% | 5 | - | $3,352 | $64,218 | 2 | N/A | false | false |
| 13 | 7 | The Unborn | $13,326 | -58.8% | 9 | -6 | $1,480 | $1,603,231 | 7 | United International Pictures | false | false |
| 14 | 11 | Night at the Museum: Battle of the Smithsonian | $9,796 | -19.7% | 6 | -5 | $1,632 | $4,366,516 | 10 | 20th Century Fox International | false | false |
| 15 | - | The Secret Life of Bees | $9,160 | - | 2 | - | $4,580 | $19,264 | 1 | 20th Century Fox International | true | false |
| 16 | 10 | Impy's Island | $8,669 | -48% | 10 | - | $866 | $211,270 | 5 | N/A | false | false |
| 17 | 14 | Terminator Salvation | $3,111 | -53.3% | 3 | -4 | $1,037 | $2,676,063 | 8 | Sony Pictures Releasing | false | false |
| 18 | 15 | In Bruges | $2,477 | -59.6% | 1 | -2 | $2,477 | $163,385 | 6 | N/A | false | false |
| 19 | 12 | Duplicity | $2,299 | -76.5% | 2 | -7 | $1,149 | $613,906 | 6 | United International Pictures | false | false |
| 20 | 16 | Angels & Demons | $360 | -56.3% | 1 | -1 | $360 | $4,444,803 | 11 | Sony Pictures Releasing | false | false |
