| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Ice Age: Dawn of the Dinosaurs | $286,526 | -56.5% | 50 | +3 | $5,730 | $6,664,262 | 5 | 20th Century Fox International | false | false |
| 2 | 3 | Harry Potter and the Half-Blood Prince | $251,146 | -59.3% | 46 | - | $5,459 | $3,364,155 | 3 | Warner Bros. | false | false |
| 3 | 4 | G-Force | $247,018 | -34.4% | 45 | -1 | $5,489 | $755,742 | 2 | Walt Disney Pictures | false | false |
| 4 | - | Public Enemies | $150,104 | - | 33 | - | $4,548 | $290,877 | 1 | United International Pictures | true | false |
| 5 | 5 | Grade 3 | $91,371 | -26.6% | 41 | +2 | $2,228 | $1,101,154 | 4 | N/A | false | false |
| 6 | 1 | Up | $69,056 | -96% | 33 | - | $2,092 | $5,013,590 | 8 | Walt Disney Pictures | false | false |
| 7 | 6 | Transformers: Revenge of the Fallen | $21,046 | -66% | 15 | -10 | $1,403 | $2,065,227 | 6 | United International Pictures | false | false |
| 8 | - | Then She Found Me | $17,978 | - | 9 | - | $1,997 | $26,142 | 1 | N/A | true | false |
| 9 | 8 | Summer Hours | $7,858 | -21.6% | 3 | +2 | $2,619 | $91,990 | 5 | Transeuropa | false | false |
| 10 | 7 | I Love You, Man | $3,655 | -82.2% | 8 | -5 | $456 | $30,812 | 15 | United International Pictures | false | false |
| 11 | 9 | Angels & Demons | $1,020 | -54.1% | 1 | - | $1,020 | $2,211,285 | 12 | Sony Pictures Releasing | false | false |
| 12 | 10 | Teresa: Crucificada por amar | $692 | -56.7% | 3 | +2 | $230 | $66,639 | 7 | N/A | false | false |
