| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Public Enemies | $50,042 | - | 6 | - | $8,340 | $50,042 | 1 | United International Pictures | true | false |
| 2 | - | G-Force | $49,284 | - | 6 | - | $8,214 | $49,284 | 1 | Walt Disney Pictures | true | false |
| 3 | 1 | Harry Potter and the Half-Blood Prince | $34,199 | -68% | 7 | - | $4,885 | $191,270 | 2 | Warner Bros. | false | false |
| 4 | 4 | The Hangover | $27,635 | -8.8% | 5 | -1 | $5,527 | $259,746 | 4 | Warner Bros. | false | false |
| 5 | - | 1000 Congratulations | $27,222 | - | 5 | - | $5,444 | $27,222 | 1 | N/A | true | false |
| 6 | 3 | Omar & Salma | $25,582 | -20.7% | 8 | -1 | $3,197 | $647,679 | 8 | N/A | false | false |
| 7 | 2 | Ice Age: Dawn of the Dinosaurs | $20,342 | -58.2% | 6 | - | $3,390 | $503,157 | 5 | 20th Century Fox International | false | false |
| 8 | 5 | The Proposal | $19,226 | -2.8% | 6 | - | $3,204 | $299,158 | 7 | Walt Disney Pictures | false | false |
| 9 | - | The Accidental Husband | $12,641 | - | 4 | - | $3,160 | $12,641 | 1 | N/A | true | false |
| 10 | 6 | Bobbos | $7,996 | -53.2% | 5 | -2 | $1,599 | $108,871 | 4 | N/A | false | false |
| 11 | 7 | Transformers: Revenge of the Fallen | $5,828 | -60.7% | 3 | -3 | $1,942 | $266,938 | 6 | United International Pictures | false | false |
| 12 | 8 | 17 Again | $5,008 | -65.6% | 3 | -1 | $1,669 | $61,038 | 3 | N/A | false | false |
| 13 | 10 | My Life in Ruins | $2,540 | -47.1% | 1 | - | $2,540 | $55,854 | 6 | Prime Pictures | false | false |
| 14 | - | The Criminal | $2,385 | - | 1 | - | $2,385 | $18,766 | 3 | N/A | false | false |
| 15 | - | Arn: The Knight Templar | $1,912 | - | 3 | - | $637 | $12,392 | 3 | Italian International Film | false | false |
| 16 | - | Up | $1,742 | - | 3 | - | $580 | $153,273 | 8 | Walt Disney Pictures | false | false |
| 17 | 12 | The Taking of Pelham 123 | $1,737 | +467.6% | 2 | +1 | $868 | $75,788 | 8 | Sony Pictures Releasing | false | false |
| 18 | - | Blindness | $1,119 | - | 4 | - | $279 | $6,736 | 2 | Italian International Film | false | false |
| 19 | 11 | Obsessed | $983 | +10.1% | 2 | - | $491 | $19,905 | 5 | Sony Pictures Releasing | false | false |
| 20 | - | Defiance | $662 | - | 2 | - | $331 | $31,748 | 12 | N/A | false | false |
| 21 | 9 | Red Cliff | $419 | -93.6% | 1 | -3 | $419 | $26,419 | 3 | Jaguar Film International Distribution | false | false |
| 22 | 13 | Angels & Demons | $187 | -15% | 1 | - | $187 | $189,627 | 12 | Sony Pictures Releasing | false | false |
| 23 | - | Dukan Shehata | $120 | - | 1 | - | $120 | $45,870 | 6 | N/A | false | false |
