| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $21,920 | -68.8% | 6 | - | $3,653 | $140,595 | 2 | - | false | false |
| 2 | - | Ice Age: Dawn of the Dinosaurs | $19,178 | -34.9% | 12 | - | $1,598 | $657,656 | 5 | - | false | false |
| 3 | - | The Proposal | $10,724 | -4.1% | 3 | - | $3,574 | $93,685 | 4 | - | false | false |
| 4 | - | Easy Virtue | $8,577 | - | 1 | - | $8,577 | $8,577 | 1 | - | true | false |
| 5 | - | Public Enemies | $7,153 | -19.6% | 4 | - | $1,788 | $86,388 | 4 | - | false | false |
| 6 | - | Brüno | $6,974 | -22.4% | 3 | - | $2,324 | $68,820 | 3 | - | false | false |
| 7 | - | The Hangover | $5,132 | -13.1% | 3 | - | $1,710 | $181,953 | 8 | - | false | false |
| 8 | - | Dorothy Mills | $2,821 | - | 1 | - | $2,821 | $2,821 | 1 | ACME | true | false |
| 9 | - | Fighting | $2,537 | -14.9% | 2 | - | $1,268 | $19,493 | 3 | - | false | false |
| 10 | - | Transformers: Revenge of the Fallen | $2,357 | -20.4% | 5 | - | $471 | $136,243 | 6 | - | false | false |
| 11 | - | Ghosts of Girlfriends Past | $2,314 | -28.5% | 2 | - | $1,157 | $49,334 | 5 | - | false | false |
