| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $666,373 | -35% | 90 | -2 | $7,404 | $9,441,775 | 5 | 20th Century Fox International | false | false |
| 2 | - | G-Force | $560,887 | - | 58 | - | $9,670 | $560,887 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $505,765 | -48.8% | 82 | - | $6,167 | $5,403,671 | 3 | Warner Bros. | false | false |
| 4 | - | State of Play | $157,716 | - | 45 | - | $3,504 | $180,619 | 1 | United International Pictures | true | false |
| 5 | 3 | 17 Again | $115,215 | -30% | 18 | -2 | $6,400 | $457,096 | 2 | N/A | false | false |
| 6 | 4 | Transporter 3 | $76,693 | -44% | 22 | -1 | $3,486 | $352,372 | 2 | N/A | false | false |
| 7 | - | Righteous Kill | $61,165 | - | 10 | - | $6,116 | $61,165 | 1 | N/A | true | false |
| 8 | 6 | I Love You, Man | $37,913 | -67.9% | 23 | -8 | $1,648 | $293,650 | 2 | United International Pictures | false | false |
| 9 | - | Libertador Morales, el justiciero | $30,705 | - | 14 | - | $2,193 | $30,705 | 1 | N/A | true | false |
| 10 | 7 | Up | $28,602 | -71.7% | 33 | -12 | $866 | $7,178,174 | 9 | Walt Disney Pictures | false | false |
| 11 | 5 | Transformers: Revenge of the Fallen | $25,459 | -80.3% | 17 | -10 | $1,497 | $3,999,842 | 6 | United International Pictures | false | false |
| 12 | 9 | The Last House on the Left | $17,833 | -59.8% | 13 | -11 | $1,371 | $503,142 | 4 | United International Pictures | false | false |
| 13 | 8 | El ratón Pérez 2 | $17,296 | -74.6% | 28 | -2 | $617 | $144,660 | 2 | Walt Disney Pictures | false | false |
| 14 | 11 | The Other Boleyn Girl | $11,087 | -45.6% | 3 | -2 | $3,695 | $164,515 | 4 | N/A | false | false |
| 15 | 15 | The Secret Life of Bees | $7,789 | -15% | 1 | -1 | $7,789 | $30,474 | 2 | 20th Century Fox International | false | false |
| 16 | 10 | Push | $3,346 | -90.9% | 6 | -11 | $557 | $325,103 | 17 | N/A | false | false |
| 17 | 13 | The Unborn | $2,910 | -78.2% | 6 | -3 | $485 | $1,615,077 | 8 | United International Pictures | false | false |
| 18 | 18 | In Bruges | $2,852 | +15.1% | 3 | +2 | $950 | $168,442 | 7 | N/A | false | false |
| 19 | 16 | Impy's Island | $2,500 | -71.2% | 7 | -3 | $357 | $218,721 | 6 | N/A | false | false |
| 20 | 14 | Night at the Museum: Battle of the Smithsonian | $2,053 | -79% | 3 | -3 | $684 | $4,372,866 | 11 | 20th Century Fox International | false | false |
| 21 | 12 | The Wrestler | $1,770 | -89.4% | 1 | -4 | $1,770 | $75,544 | 3 | N/A | false | false |
| 22 | 17 | Terminator Salvation | $997 | -68% | 2 | -1 | $498 | $2,679,579 | 9 | Sony Pictures Releasing | false | false |
