| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | The Hangover | $240,800 | -45.4% | 77 | +27 | $3,127 | $2,744,287 | 8 | Warner Bros. | false | false |
| 2 | - | My Bloody Valentine | $236,606 | - | 18 | - | $13,144 | $236,606 | 1 | N/A | true | false |
| 3 | 1 | Ice Age: Dawn of the Dinosaurs | $217,447 | -64.2% | 96 | -10 | $2,265 | $13,999,976 | 7 | 20th Century Fox International | false | false |
| 4 | 3 | The Proposal | $201,554 | -48% | 55 | - | $3,664 | $1,462,989 | 3 | Walt Disney Pictures | false | false |
| 5 | 4 | Harry Potter and the Half-Blood Prince | $172,874 | -54.3% | 81 | -23 | $2,134 | $6,126,878 | 5 | Warner Bros. | false | false |
| 6 | 5 | Up | $145,821 | -42.5% | 31 | - | $4,703 | $1,056,614 | 3 | Walt Disney Pictures | false | false |
| 7 | 6 | G.I. Joe: The Rise of Cobra | $96,146 | -56% | 45 | -5 | $2,136 | $408,952 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | - | Broken Embraces | $67,440 | - | 11 | - | $6,130 | $456,335 | 1 | N/A | true | false |
| 9 | - | Whatever Works | $52,620 | - | 10 | - | $5,262 | $122,901 | 1 | N/A | true | false |
| 10 | - | The Hurt Locker | $43,385 | - | 17 | - | $2,552 | $43,385 | 1 | N/A | true | false |
| 11 | 9 | The Taking of Pelham 123 | $38,978 | -40.4% | 14 | - | $2,784 | $264,966 | 3 | Sony Pictures Releasing | false | false |
| 12 | 8 | Brüno | $23,692 | -68.6% | 20 | -31 | $1,184 | $2,357,912 | 4 | N/A | false | false |
| 13 | - | State of Play | $19,400 | - | 6 | - | $3,233 | $1,187,691 | 9 | Universal Pictures International (UPI) | false | false |
| 14 | - | Crank: High Voltage | $15,629 | - | 8 | - | $1,953 | $973,773 | 1 | N/A | true | false |
| 15 | - | Bandslam | $15,031 | - | 8 | - | $1,878 | $17,980 | 1 | N/A | true | false |
| 16 | - | The Girl with the Dragon Tattoo | $12,780 | - | 3 | - | $4,260 | $513,726 | 14 | N/A | false | false |
| 17 | 7 | Public Enemies | $12,543 | -93.9% | 8 | -43 | $1,567 | $1,108,599 | 6 | Universal Pictures International (UPI) | false | false |
