| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | G.I. Joe: The Rise of Cobra | $398,071 | -30.9% | 40 | - | $9,951 | $1,269,900 | 2 | United International Pictures | false | false |
| 2 | - | The Taking of Pelham 123 | $181,990 | - | 25 | - | $7,279 | $193,789 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Up | $148,250 | -40.7% | 39 | -5 | $3,801 | $1,288,018 | 3 | Walt Disney Pictures | false | false |
| 4 | - | Orphan | $89,119 | - | 31 | - | $2,874 | $94,255 | 1 | Warner Bros. | true | false |
| 5 | 4 | Aliens in the Attic | $30,339 | -57.7% | 18 | -12 | $1,685 | $162,688 | 2 | 20th Century Fox International | false | false |
| 6 | - | The Proposal | $16,755 | - | 30 | - | $558 | $16,755 | - | Walt Disney Pictures | - | false |
| 7 | 3 | Harry Potter and the Half-Blood Prince | $15,882 | -79.7% | 25 | -14 | $635 | $3,556,527 | 5 | Warner Bros. | false | false |
| 8 | 5 | Public Enemies | $10,803 | -40.8% | 9 | -1 | $1,200 | $623,211 | 4 | United International Pictures | false | false |
| 9 | 6 | Transformers: Revenge of the Fallen | $8,845 | +14.5% | 3 | -2 | $2,948 | $4,519,921 | 8 | United International Pictures | false | false |
| 10 | 8 | Ice Age: Dawn of the Dinosaurs | $8,652 | +134.2% | 3 | - | $2,884 | $2,112,733 | 7 | 20th Century Fox International | false | false |
| 11 | - | Land of the Lost | $3,450 | - | 15 | - | $230 | $3,450 | - | United International Pictures | - | false |
| 12 | 9 | I Love You, Beth Cooper | $10 | -99.5% | 1 | -4 | $10 | $58,378 | 3 | 20th Century Fox International | false | false |
