| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | G.I. Joe: The Rise of Cobra | $4,687,361 | - | 756 | - | $6,200 | $4,687,361 | 1 | Central Partnership | true | false |
| 2 | - | OceanWorld | $531,546 | - | 117 | - | $4,543 | $531,546 | 1 | Luxor Entertainment | true | false |
| 3 | 3 | Ghosts of Girlfriends Past | $500,788 | -51.1% | 315 | -1 | $1,589 | $2,015,003 | 9 | Karo Premiere | false | false |
| 4 | 4 | Ice Age: Dawn of the Dinosaurs | $454,041 | -29.3% | 280 | +80 | $1,621 | $43,967,239 | 6 | 20th Century Fox International | false | false |
| 5 | 2 | Harry Potter and the Half-Blood Prince | $388,915 | -63.1% | 439 | -193 | $885 | $18,244,478 | 4 | Karo Premiere | false | false |
| 6 | 1 | Public Enemies | $365,286 | -65.7% | 307 | -108 | $1,189 | $5,290,345 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | - | Aliens in the Attic | $307,378 | - | 351 | - | $875 | $1,074,187 | - | 20th Century Fox International | - | false |
| 8 | 6 | Funny People | $198,445 | -48.8% | 207 | +4 | $958 | $793,977 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Drag Me to Hell | $74,815 | -38.4% | 119 | -47 | $628 | $2,444,031 | 5 | West Video | false | false |
| 10 | 13 | Broken Embraces | $53,268 | +113% | 31 | +3 | $1,718 | $1,065,313 | 5 | Paradise Group | false | false |
| 11 | 7 | Brüno | $43,280 | -80.3% | 80 | -153 | $541 | $1,103,705 | 3 | Central Partnership | false | false |
| 12 | - | LOL (Laughing Out Loud) | $37,595 | - | 32 | - | $1,174 | $37,595 | 1 | N/A | true | false |
| 13 | 12 | Oxygen | $21,750 | -55.4% | 48 | -2 | $453 | $91,513 | 2 | N/A | false | false |
| 14 | - | Two Lovers | $17,561 | - | 7 | - | $2,508 | $17,561 | 1 | Cascade Film | true | false |
| 15 | 11 | Paul Blart: Mall Cop | $16,577 | -69.9% | 38 | -53 | $436 | $249,189 | 3 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 16 | 15 | Sex Drive | $15,541 | -34.9% | 47 | -18 | $330 | $641,640 | 4 | Central Partnership | false | false |
| 17 | - | Antichrist | $12,163 | - | 10 | - | $1,216 | $275,717 | - | CP Classics | - | false |
| 18 | 14 | The Proposal | $10,755 | -55.7% | 15 | -13 | $717 | $7,566,398 | 8 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 19 | 20 | Transformers: Revenge of the Fallen | $9,415 | -19.9% | 20 | -40 | $470 | $18,160,384 | 7 | Central Partnership | false | false |
| 20 | 18 | Lyubov.ru | $9,279 | -45.3% | 26 | -24 | $356 | $36,243 | 2 | N/A | false | false |
| 21 | 10 | Get That Girl | $9,076 | -86.6% | 39 | -145 | $232 | $335,115 | 3 | N/A | false | false |
| 22 | 16 | Fighting | $8,308 | -65.1% | 42 | -38 | $197 | $589,549 | 5 | Universal Pictures International (UPI) | false | false |
| 23 | 19 | The Hangover | $5,972 | -62.1% | 12 | -11 | $497 | $5,220,629 | 2 | Karo Premiere | false | false |
| 24 | 9 | City Island | $4,344 | -96.3% | 26 | -75 | $167 | $457,402 | 3 | Paradise Group | false | false |
| 25 | 22 | Pete on the Way to Heaven | $3,751 | -45% | 11 | +6 | $341 | $12,442 | 2 | N/A | false | false |
| 26 | 21 | Labor Pains | $3,740 | -56.5% | 24 | -23 | $155 | $678,014 | 5 | Cascade Film | false | false |
| 27 | 26 | Country Wedding | $3,651 | +8.9% | 2 | - | $1,825 | $13,980 | 3 | Russian Report | false | false |
| 28 | 23 | 9 1/2 Dates 2009 Re-release | $3,113 | -50.4% | 2 | - | $1,556 | $9,364 | 2 | N/A | false | false |
| 29 | - | Room and a Half | $2,321 | - | 2 | - | $1,160 | $75,367 | 18 | Paradise Group | false | false |
| 30 | 24 | Paris 36 | $2,300 | -63.1% | 5 | -8 | $460 | $33,058 | 13 | Volga | false | false |
| 31 | 28 | Up | $1,626 | -36.2% | 8 | -4 | $203 | $12,112,913 | 11 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
| 32 | 31 | Departures | $1,360 | +23.2% | 2 | - | $680 | $20,844 | 5 | Russian Report | false | false |
| 33 | - | Robert Zimmermann wundert sich über die Liebe | $984 | - | 1 | - | $984 | $984 | 1 | N/A | true | false |
| 34 | 27 | My Bloody Valentine | $975 | -62% | 1 | -2 | $975 | $2,093,298 | 18 | Central Partnership | false | false |
| 35 | 30 | State of Play | $661 | -55.8% | 5 | -3 | $132 | $434,296 | 11 | Universal Pictures International (UPI) | false | false |
| 36 | 35 | Three Monkeys | $267 | -46.2% | 2 | - | $133 | $21,139 | 10 | N/A | false | false |
| 37 | 34 | Palermo Shooting | $267 | -49.4% | 1 | - | $267 | $23,820 | 8 | N/A | false | false |
| 38 | 37 | Waltz with Bashir | $229 | -35.3% | 1 | -1 | $229 | $17,116 | 8 | Cinema Without Frontiers | false | false |
| 39 | - | Dead Snow | $222 | - | 1 | - | $222 | $85,693 | 14 | Volga | false | false |
| 40 | 32 | Terminator Salvation | $216 | -72.5% | 3 | -5 | $72 | $14,534,839 | 10 | Walt Disney Studios Sony Pictures Releasing (WDSSPR) | false | false |
