| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $31,139 | +51.1% | 10 | -2 | $3,113 | $1,262,672 | 7 | Universal Pictures International (UPI) | false | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $14,530 | - | 4 | - | $3,632 | $14,530 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | My Sister's Keeper | $12,114 | -6.8% | 4 | - | $3,028 | $44,913 | 2 | - | false | false |
| 4 | - | Year One | $9,244 | - | 7 | - | $1,320 | $50,448 | - | Sony Pictures Releasing | - | false |
| 5 | 4 | Harry Potter and the Half-Blood Prince | $8,068 | -4% | 8 | - | $1,008 | $269,825 | 4 | Garsu Pasaulio Irasai | false | false |
| 6 | 5 | The Taking of Pelham 123 | $6,282 | -15.9% | 7 | - | $897 | $56,061 | 3 | Sony Pictures Releasing | false | false |
| 7 | 6 | Brüno | $5,491 | -11.1% | 7 | - | $784 | $135,959 | 4 | ACME | false | false |
| 8 | 7 | Diary of a Nymphomaniac | $4,302 | +35% | 2 | - | $2,151 | $14,027 | 2 | ACME | false | false |
| 9 | 10 | Fly Me to the Moon 3D | $4,181 | +176.5% | 3 | +1 | $1,393 | $100,099 | 30 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Hannah Montana: The Movie | $2,124 | +18.9% | 3 | - | $708 | $23,321 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 12 | The Hangover | $1,936 | +31.3% | 5 | +1 | $387 | $289,437 | 10 | - | false | false |
| 12 | 13 | The Last House on the Left | $1,716 | +29.1% | 3 | - | $572 | $23,320 | 4 | Universal Pictures International (UPI) | false | false |
| 13 | 8 | Easy Virtue | $1,270 | -30% | 2 | - | $635 | $14,777 | 3 | ACME | false | false |
| 14 | 11 | Public Enemies | $1,190 | -19.5% | 5 | -1 | $238 | $87,261 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | 15 | Gomorrah | $911 | +67.8% | 2 | - | $455 | $22,600 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | 14 | The Proposal | $722 | -2.7% | 2 | - | $361 | $154,759 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | 16 | Transformers: Revenge of the Fallen | $343 | -35.5% | 2 | -2 | $171 | $220,242 | 8 | Universal Pictures International (UPI) | false | false |
| 18 | 17 | U2 3D | $300 | -28.4% | 1 | -1 | $300 | $33,116 | 30 | Universal Pictures International (UPI) | false | false |
| 19 | 18 | The Uninvited | $113 | +101.8% | 1 | - | $113 | $22,666 | 13 | Universal Pictures International (UPI) | false | false |
| 20 | - | Monsters vs. Aliens | $98 | - | 1 | - | $98 | $228,889 | 20 | Universal Pictures International (UPI) | false | false |
| 21 | 20 | Beverly Hills Chihuahua | $74 | +640% | 1 | - | $74 | $136,136 | 28 | Universal Pictures International (UPI) | false | false |
