| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $23,080 | -32.1% | 9 | - | $2,564 | $90,881 | 2 | - | false | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $18,971 | - | 3 | - | $6,323 | $18,971 | 1 | - | true | false |
| 3 | 3 | Ice Age: Dawn of the Dinosaurs | $12,377 | +35.6% | 12 | - | $1,031 | $704,971 | 7 | - | false | false |
| 4 | 5 | The Proposal | $8,630 | +21.1% | 3 | - | $2,876 | $129,619 | 6 | - | false | false |
| 5 | 2 | Harry Potter and the Half-Blood Prince | $8,430 | -20.5% | 6 | - | $1,405 | $198,494 | 4 | - | false | false |
| 6 | - | Two Lovers | $7,711 | - | 1 | - | $7,711 | $7,711 | 1 | ACME | true | false |
| 7 | 4 | The Taking of Pelham 123 | $7,382 | -13.2% | 2 | - | $3,691 | $24,957 | 2 | Sony Pictures Releasing | false | false |
| 8 | 6 | Public Enemies | $6,016 | +39.5% | 4 | - | $1,504 | $109,391 | 6 | - | false | false |
| 9 | 7 | Easy Virtue | $4,647 | +8.1% | 1 | - | $4,647 | $33,315 | 3 | - | false | false |
| 10 | 9 | The Hangover | $3,982 | +35% | 3 | - | $1,327 | $197,242 | 10 | - | false | false |
| 11 | 8 | Brüno | $3,649 | +12.4% | 3 | - | $1,216 | $86,555 | 5 | - | false | false |
| 12 | 10 | Ghosts of Girlfriends Past | $2,820 | +43.5% | 2 | - | $1,410 | $58,528 | 7 | - | false | false |
