| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Drag Me to Hell | $100,295 | -64.7% | 21 | +1 | $4,775 | $485,154 | 2 | Gulf Film | false | false |
| 2 | 2 | G.I. Joe: The Rise of Cobra | $95,925 | -52.9% | 20 | -2 | $4,796 | $1,082,919 | 3 | United International Pictures | false | false |
| 3 | 3 | Funny People | $64,802 | -57.5% | 18 | -2 | $3,600 | $269,505 | 2 | United International Pictures | false | false |
| 4 | 4 | The Hangover | $49,109 | -31.1% | 8 | +1 | $6,138 | $831,006 | 4 | Warner Bros. | false | false |
| 5 | - | The Alphabet Killer | $28,081 | - | 8 | - | $3,510 | $28,081 | 1 | Gulf Film | true | false |
| 6 | 9 | G-Force | $25,833 | -15.9% | 7 | +3 | $3,690 | $450,039 | 5 | Walt Disney Pictures | false | false |
| 7 | 7 | Ice Age: Dawn of the Dinosaurs | $23,835 | -29.6% | 4 | +1 | $5,958 | $1,386,573 | 8 | 20th Century Fox International | false | false |
| 8 | 6 | 1000 Congratulations | $20,258 | -53.2% | 9 | -3 | $2,250 | $1,023,974 | 5 | Gulf Film | false | false |
| 9 | 5 | My Sister's Keeper | $16,816 | -70.7% | 4 | -8 | $4,204 | $104,337 | 2 | Warner Bros. | false | false |
| 10 | 11 | My Best Friend's Girl | $12,000 | -26.3% | 8 | -1 | $1,500 | $114,434 | 3 | Gulf Film | false | false |
| 11 | 16 | Transformers: Revenge of the Fallen | $11,454 | +116.5% | 7 | +4 | $1,636 | $2,251,206 | 9 | United International Pictures | false | false |
| 12 | 14 | Imagine That | $9,795 | -28.6% | 11 | -1 | $890 | $315,963 | 4 | United International Pictures | false | false |
| 13 | 13 | Two Lovers | $7,911 | -44.4% | 3 | -8 | $2,637 | $28,912 | 2 | Gulf Film | false | false |
| 14 | 12 | Harry Potter and the Half-Blood Prince | $7,441 | -48.5% | 1 | - | $7,441 | $1,432,041 | 6 | Warner Bros. | false | false |
| 15 | 8 | My Life in Ruins | $6,049 | -81.9% | 3 | -9 | $2,016 | $54,125 | 2 | N/A | false | false |
| 16 | 22 | Public Enemies | $5,135 | +222.8% | 1 | - | $5,135 | $587,655 | 5 | United International Pictures | false | false |
| 17 | 25 | Che: Part Two | $3,696 | +236.3% | 6 | +5 | $616 | $24,448 | 3 | Gulf Film | false | false |
| 18 | 15 | Fighting | $2,633 | -59.9% | 2 | -2 | $1,316 | $280,502 | 4 | Gulf Film | false | false |
| 19 | 19 | Land of the Lost | $2,463 | +32.6% | 1 | - | $2,463 | $556,873 | 7 | United International Pictures | false | false |
| 20 | 21 | My Bloody Valentine | $2,167 | +26.7% | 1 | - | $2,167 | $278,084 | 6 | Gulf Film | false | false |
| 21 | 23 | Ghosts of Girlfriends Past | $1,297 | -16.9% | 1 | - | $1,297 | $421,664 | 6 | Gulf Film | false | false |
| 22 | 24 | The Missing Lynx | $1,048 | -15.5% | 1 | - | $1,048 | $115,468 | 8 | Gulf Film | false | false |
