| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $45,298 | - | 5 | - | $9,059 | $45,298 | 1 | United International Pictures | true | false |
| 2 | 1 | Up | $18,421 | -46.4% | 8 | -1 | $2,302 | $171,350 | 3 | Walt Disney Pictures | false | false |
| 3 | 3 | Ice Age: Dawn of the Dinosaurs | $8,819 | -56.8% | 6 | -1 | $1,469 | $1,117,205 | 8 | 20th Century Fox International | false | false |
| 4 | - | Spread | $7,751 | - | 1 | - | $7,751 | $7,751 | 1 | N/A | true | false |
| 5 | 2 | District 9 | $6,843 | -68.4% | 2 | - | $3,421 | $45,280 | 2 | Sony Pictures Releasing | false | false |
| 6 | 4 | The Proposal | $5,719 | -49.7% | 4 | - | $1,429 | $161,609 | 6 | Walt Disney Pictures | false | false |
| 7 | 5 | Harry Potter and the Half-Blood Prince | $5,386 | -41.6% | 5 | -1 | $1,077 | $204,875 | 5 | Warner Bros. | false | false |
| 8 | - | Two Lovers | $2,603 | - | 1 | - | $2,603 | $2,603 | 1 | N/A | true | false |
| 9 | 6 | Brüno | $1,761 | -72% | 3 | - | $587 | $232,777 | 7 | N/A | false | false |
| 10 | 9 | The Hangover | $1,735 | -40.3% | 1 | - | $1,735 | $200,850 | 10 | Warner Bros. | false | false |
| 11 | 7 | The Taking of Pelham 123 | $1,214 | -65.5% | 2 | - | $607 | $34,538 | 4 | Sony Pictures Releasing | false | false |
| 12 | 11 | Paul Blart: Mall Cop | $590 | -33.6% | 1 | -1 | $590 | $16,513 | 5 | Sony Pictures Releasing | false | false |
