| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Proposal | $171,156 | -13.7% | 30 | - | $5,705 | $527,193 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | G.I. Joe: The Rise of Cobra | $84,088 | -54.1% | 40 | - | $2,102 | $1,868,450 | 4 | United International Pictures | false | false |
| 3 | - | The Hangover | $79,792 | - | 15 | - | $5,319 | $102,500 | 1 | Warner Bros. | true | false |
| 4 | 3 | Orphan | $63,408 | -28% | 30 | -1 | $2,113 | $394,291 | 3 | Warner Bros. | false | false |
| 5 | 6 | Land of the Lost | $37,845 | -13.6% | 15 | - | $2,523 | $102,195 | 2 | United International Pictures | false | false |
| 6 | 4 | The Taking of Pelham 123 | $25,282 | -70.7% | 22 | -3 | $1,149 | $385,413 | 3 | Sony Pictures Releasing | false | false |
| 7 | 5 | Up | $19,328 | -71.4% | 12 | -13 | $1,610 | $1,490,781 | 5 | Walt Disney Pictures | false | false |
| 8 | 7 | Ice Age: Dawn of the Dinosaurs | $7,555 | -23.4% | 2 | -4 | $3,777 | $2,144,675 | 9 | 20th Century Fox International | false | false |
| 9 | 11 | Public Enemies | $4,435 | +315.7% | 2 | +1 | $2,217 | $636,879 | 6 | United International Pictures | false | false |
| 10 | 8 | Harry Potter and the Half-Blood Prince | $2,927 | -58.9% | 2 | -7 | $1,463 | $3,587,324 | 7 | Warner Bros. | false | false |
| 11 | 10 | Transformers: Revenge of the Fallen | $725 | -85% | 1 | -5 | $725 | $4,536,529 | 10 | United International Pictures | false | false |
| 12 | 9 | Aliens in the Attic | $142 | -97.6% | 1 | -7 | $142 | $188,104 | 4 | 20th Century Fox International | false | false |
