| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $22,265 | - | 3 | - | $7,421 | $22,265 | 1 | - | true | false |
| 2 | 1 | Up | $14,300 | -38% | 9 | - | $1,588 | $131,837 | 3 | - | false | false |
| 3 | - | Spread | $10,628 | - | 1 | - | $10,628 | $10,628 | 1 | ACME | true | false |
| 4 | 3 | Ice Age: Dawn of the Dinosaurs | $7,615 | -38.5% | 12 | - | $634 | $737,946 | 8 | - | false | false |
| 5 | 2 | G.I. Joe: The Rise of Cobra | $6,579 | -65.3% | 3 | - | $2,193 | $39,907 | 2 | - | false | false |
| 6 | 4 | The Proposal | $5,955 | -31% | 3 | - | $1,985 | $148,199 | 7 | - | false | false |
| 7 | 5 | Harry Potter and the Half-Blood Prince | $4,848 | -42.5% | 6 | - | $808 | $217,441 | 5 | - | false | false |
| 8 | 7 | The Taking of Pelham 123 | $3,637 | -50.7% | 2 | - | $1,818 | $35,459 | 3 | Sony Pictures Releasing | false | false |
| 9 | 6 | Two Lovers | $3,101 | -59.8% | 1 | - | $3,101 | $19,040 | 2 | ACME | false | false |
| 10 | 10 | The Hangover | $2,509 | -37% | 3 | - | $836 | $206,707 | 11 | - | false | false |
| 11 | 8 | Public Enemies | $2,493 | -58.6% | 4 | - | $623 | $119,993 | 7 | - | false | false |
| 12 | 9 | Easy Virtue | $1,918 | -58.7% | 1 | - | $1,918 | $41,471 | 4 | - | false | false |
