| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | So Normal 2: The Craziest Night Ever | $1,931,814 | - | 437 | - | $4,420 | $1,931,814 | 1 | N/A | true | false |
| 2 | 1 | The Hangover | $750,578 | -27.1% | 182 | -32 | $4,124 | $2,264,291 | 2 | Warner Bros. | false | false |
| 3 | 2 | G-Force | $585,187 | -35.9% | 298 | -1 | $1,963 | $3,309,235 | 3 | Walt Disney Pictures | false | false |
| 4 | 3 | Drag Me to Hell | $176,343 | -49.4% | 191 | - | $923 | $1,426,901 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | - | Two Lovers | $147,651 | - | 50 | - | $2,953 | $147,651 | 1 | PlayArte Pictures | true | false |
| 6 | 4 | G.I. Joe: The Rise of Cobra | $145,446 | -57.2% | 249 | -56 | $584 | $3,222,000 | 4 | Paramount Pictures International | false | false |
| 7 | 6 | Ice Age: Dawn of the Dinosaurs | $130,378 | -45.7% | 218 | -82 | $598 | $44,181,500 | 9 | 20th Century Fox International | false | false |
| 8 | 5 | Brüno | $113,528 | -53.2% | 82 | -7 | $1,384 | $961,752 | 3 | Sony Pictures Releasing | false | false |
| 9 | 7 | The Proposal | $88,502 | -51.7% | 131 | -15 | $675 | $6,979,646 | 8 | Walt Disney Pictures | false | false |
| 10 | - | Shorts | $86,638 | - | 61 | - | $1,420 | $86,638 | 1 | Warner Bros. | true | false |
| 11 | 9 | Harry Potter and the Half-Blood Prince | $44,369 | -61.2% | 74 | -131 | $599 | $19,987,936 | 7 | Warner Bros. | false | false |
| 12 | 8 | The Accidental Husband | $38,250 | -66.7% | 95 | -25 | $402 | $1,050,220 | 4 | PlayArte Pictures | false | false |
| 13 | 13 | The Invisible Woman | $29,223 | -50.5% | 70 | -21 | $417 | $11,104,205 | 13 | Warner Bros. | false | false |
| 14 | 11 | Time of Peace | $28,329 | -64.6% | 51 | -2 | $555 | $323,528 | 3 | N/A | false | false |
| 15 | 14 | The Story of Me | $24,864 | -52.8% | 62 | -23 | $401 | $490,538 | 4 | Warner Bros. | false | false |
| 16 | 19 | Last Chance Harvey | $22,025 | +8.8% | 27 | +11 | $815 | $762,502 | 11 | N/A | false | false |
| 17 | 15 | Public Enemies | $20,137 | -58% | 50 | -38 | $402 | $2,798,028 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 12 | Doomsday | $19,959 | -72.6% | 56 | -10 | $356 | $134,066 | 2 | Europa Filmes | false | false |
| 19 | 16 | The Butterfly Effect 3: Revelations | $18,292 | -51.5% | 41 | -20 | $446 | $589,448 | 5 | N/A | false | false |
