| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inglourious Basterds | $20,389 | -11.1% | 6 | - | $3,398 | $71,933 | 2 | United International Pictures | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $9,683 | +1.2% | 9 | - | $1,075 | $349,216 | 9 | 20th Century Fox International | false | false |
| 3 | - | The Taking of Pelham 123 | $6,531 | - | 5 | - | $1,306 | $10,527 | 1 | Sony Pictures Releasing | true | false |
| 4 | 3 | The Proposal | $5,764 | -3.7% | 6 | - | $960 | $91,239 | 6 | Walt Disney Pictures | false | false |
| 5 | - | G-Force | $5,107 | - | 5 | - | $1,021 | $9,935 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | Harry Potter and the Half-Blood Prince | $4,767 | +15.1% | 8 | - | $595 | $179,612 | 7 | Warner Bros. | false | false |
| 7 | - | Two Lovers | $2,593 | - | 3 | - | $864 | $3,238 | 1 | N/A | true | false |
| 8 | 6 | The Hangover | $1,996 | -1.6% | 5 | - | $399 | $137,908 | 11 | Warner Bros. | false | false |
| 9 | 5 | Public Enemies | $1,965 | -16.2% | 5 | - | $393 | $68,821 | 9 | United International Pictures | false | false |
| 10 | 7 | Knowing | $1,488 | +5.5% | 4 | - | $372 | $23,580 | 5 | N/A | false | false |
| 11 | 8 | Brüno | $1,180 | -10.7% | 6 | - | $196 | $63,267 | 8 | N/A | false | false |
| 12 | 9 | State of Play | $841 | +2.1% | 4 | - | $210 | $29,782 | 12 | United International Pictures | false | false |
| 13 | 13 | Coraline | $518 | +91.9% | 4 | - | $129 | $33,314 | 13 | United International Pictures | false | false |
| 14 | 10 | Transformers: Revenge of the Fallen | $360 | -14.1% | 8 | - | $45 | $82,536 | 10 | United International Pictures | false | false |
| 15 | 12 | Hannah Montana: The Movie | $298 | -13.6% | 5 | - | $59 | $32,106 | 12 | Walt Disney Pictures | false | false |
| 16 | 16 | Angels & Demons | $290 | +34.9% | 4 | +2 | $72 | $164,153 | 16 | Sony Pictures Releasing | false | false |
| 17 | 15 | Terminator Salvation | $225 | -3% | 4 | - | $56 | $91,569 | 13 | Sony Pictures Releasing | false | false |
| 18 | 11 | Ghosts of Girlfriends Past | $176 | -54.8% | 5 | - | $35 | $56,807 | 12 | Warner Bros. | false | false |
| 19 | 14 | Slumdog Millionaire | $154 | -41.4% | 5 | - | $30 | $65,339 | 20 | N/A | false | false |
| 20 | 17 | Night at the Museum: Battle of the Smithsonian | $84 | -59.8% | 6 | - | $14 | $61,131 | 15 | 20th Century Fox International | false | false |
