| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Secret in Their Eyes | $631,327 | -7.5% | 81 | +9 | $7,794 | $3,796,652 | 4 | Distribution Company | false | false |
| 2 | - | Inglourious Basterds | $257,346 | - | 45 | - | $5,718 | $257,346 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | - | My Bloody Valentine | $226,922 | - | 60 | - | $3,782 | $226,922 | 1 | Alfa Films | true | false |
| 4 | 6 | Ice Age: Dawn of the Dinosaurs | $165,370 | +71.8% | 48 | -22 | $3,445 | $7,969,559 | 10 | 20th Century Fox International | false | false |
| 5 | - | Tinker Bell and the Lost Treasure | $151,807 | - | 47 | - | $3,229 | $151,807 | 1 | Walt Disney Pictures | true | false |
| 6 | 3 | Dad for a Day | $124,930 | +12.2% | 68 | -7 | $1,837 | $1,335,480 | 5 | Walt Disney Pictures | false | false |
| 7 | 2 | The Ugly Truth | $85,995 | -23% | 31 | - | $2,774 | $226,979 | 2 | Sony Pictures Releasing | false | false |
| 8 | 4 | Anita | $80,899 | -22.3% | 46 | - | $1,758 | $224,178 | 2 | Distribution Company | false | false |
| 9 | 7 | The Hangover | $74,041 | -19.9% | 42 | +1 | $1,762 | $662,455 | 4 | Warner Bros. | false | false |
| 10 | 5 | G-Force | $73,166 | -24% | 86 | -30 | $850 | $1,906,780 | 6 | Walt Disney Pictures | false | false |
| 11 | 8 | Coco Before Chanel | $50,312 | -16.4% | 17 | - | $2,959 | $132,226 | 2 | Warner Bros. | false | false |
| 12 | 11 | Hannah Montana: The Movie | $32,274 | -21.7% | 66 | -1 | $489 | $400,257 | 4 | Walt Disney Pictures | false | false |
| 13 | 9 | Drag Me to Hell | $26,038 | -47.3% | 35 | -1 | $743 | $391,382 | 4 | Universal Pictures International (UPI) | false | false |
| 14 | 10 | Harry Potter and the Half-Blood Prince | $25,144 | -40.2% | 28 | -31 | $898 | $4,423,043 | 7 | Warner Bros. | false | false |
| 15 | - | El hombre que corría tras el viento | $20,966 | - | 26 | - | $806 | $20,966 | 1 | Primer Plano Film Group | true | false |
| 16 | 12 | Public Enemies | $20,310 | -46.9% | 49 | -5 | $414 | $993,533 | 6 | Universal Pictures International (UPI) | false | false |
| 17 | 13 | The Haunting in Connecticut | $20,087 | -36.5% | 24 | - | $836 | $137,549 | 3 | Alfa Films | false | false |
| 18 | 15 | Aliens in the Attic | $18,846 | <0.1% | 32 | - | $588 | $94,428 | 3 | 20th Century Fox International | false | false |
| 19 | 14 | The Wave | $17,767 | -37.2% | 17 | -1 | $1,045 | $126,474 | 3 | Impacto Cine | false | false |
| 20 | - | Wild Blood | $11,340 | - | 9 | - | $1,260 | $11,340 | 1 | Pachamama Cine | true | false |
| 21 | 18 | My Sister's Keeper | $9,341 | -21.8% | 25 | - | $373 | $173,280 | 5 | Distribution Company | false | false |
| 22 | 16 | G.I. Joe: The Rise of Cobra | $7,424 | -58.8% | 26 | -25 | $285 | $446,780 | 5 | Paramount Pictures International | false | false |
| 23 | 19 | The Taking of Pelham 123 | $5,944 | -44.5% | 19 | -13 | $312 | $965,597 | 8 | Sony Pictures Releasing | false | false |
| 24 | 20 | The Girl by the Lake 2009 Re-release | $5,820 | -32.4% | 5 | - | $1,164 | $16,949 | 2 | Primer Plano Film Group | false | false |
| 25 | - | One Day You'll Understand | $4,415 | - | 4 | - | $1,103 | $4,415 | 1 | N/A | true | false |
| 26 | 17 | Zack and Miri Make a Porno | $4,271 | -72.8% | 14 | -6 | $305 | $26,122 | 2 | N/A | false | false |
| 27 | - | The Proposal | $2,814 | - | 8 | - | $351 | $884,442 | 10 | Walt Disney Pictures | false | false |
| 28 | - | Solstice | $2,270 | - | 9 | - | $252 | $284,923 | 9 | Distribution Company | false | false |
| 29 | - | State of Play | $2,225 | - | 6 | - | $370 | $532,938 | 13 | Universal Pictures International (UPI) | false | false |
| 30 | - | The Secret of the Grain | $1,574 | - | 3 | - | $524 | $76,797 | 6 | N/A | false | false |
| 31 | - | Defiance | $1,471 | - | 5 | - | $294 | $118,201 | 5 | N/A | false | false |
| 32 | - | Mentiras piadosas | $1,441 | - | 3 | - | $480 | $16,377 | 3 | N/A | false | false |
| 33 | - | A Christmas Tale | $1,285 | - | 6 | - | $214 | $88,417 | 10 | Pachamama Cine | false | false |
| 34 | - | Felicitas | $714 | - | 5 | - | $142 | $447,914 | 13 | Pachamama Cine | false | false |
| 35 | - | Last Chance Harvey | $629 | - | 2 | - | $314 | $469,886 | 14 | Distribution Company | false | false |
| 36 | - | Too Much Romance... It's Time for Stuffed Peppers | $488 | - | 2 | - | $244 | $28,491 | 5 | Primer Plano Film Group | false | false |
| 37 | - | Up | $381 | - | 1 | - | $381 | $3,428,922 | 13 | Walt Disney Pictures | false | false |
| 38 | - | The Girl in the Park | $343 | - | 2 | - | $171 | $16,413 | 3 | CDI Films | false | false |
| 39 | - | Transformers: Revenge of the Fallen | $275 | - | 2 | - | $137 | $2,485,680 | 11 | Paramount Pictures International | false | false |
| 40 | - | Days and Clouds | $183 | - | 1 | - | $183 | $96,159 | 7 | Impacto Cine | false | false |
| 41 | - | Pride and Glory | $173 | - | 2 | - | $86 | $132,929 | 11 | Distribution Company | false | false |
| 42 | - | 100% lucha, el amo de los clones | $159 | - | 3 | - | $53 | $281,638 | 8 | Primer Plano Film Group | false | false |
| 43 | - | Breath 2009 Re-release | $114 | - | 1 | - | $114 | $19,931 | 6 | Distribution Company | false | false |
| 44 | - | Che: Part Two | $114 | - | 1 | - | $114 | $53,193 | 12 | Alfa Films | false | false |
| 45 | - | Inspector Bellamy | $93 | - | 1 | - | $93 | $139,450 | 14 | Alfa Films | false | false |
| 46 | - | The Reader | $52 | - | 1 | - | $52 | $568,663 | 18 | Pachamama Cine | false | false |
