| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $1,977,772 | - | 329 | - | $6,011 | $1,977,772 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | So Normal 2: The Craziest Night Ever | $1,420,966 | -26.4% | 384 | -53 | $3,700 | $4,008,987 | 2 | N/A | false | false |
| 3 | - | The Taking of Pelham 123 | $881,218 | - | 181 | - | $4,868 | $881,218 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | The Hangover | $617,470 | -17.7% | 183 | +1 | $3,374 | $3,051,378 | 3 | Warner Bros. | false | false |
| 5 | 3 | G-Force | $189,708 | -67.6% | 221 | -77 | $858 | $3,507,626 | 4 | Walt Disney Pictures | false | false |
| 6 | - | Orphan | $171,366 | - | 81 | - | $2,115 | $171,366 | 1 | Warner Bros. | true | false |
| 7 | 5 | Two Lovers | $87,761 | -40.6% | 47 | -3 | $1,867 | $282,734 | 2 | PlayArte Pictures | false | false |
| 8 | 4 | Drag Me to Hell | $79,745 | -54.8% | 146 | -45 | $546 | $1,521,006 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Brüno | $46,363 | -59.2% | 60 | -22 | $772 | $1,039,837 | 4 | Sony Pictures Releasing | false | false |
| 10 | 6 | G.I. Joe: The Rise of Cobra | $43,528 | -70.1% | 132 | -117 | $329 | $3,189,924 | 5 | Paramount Pictures International | false | false |
| 11 | 7 | Ice Age: Dawn of the Dinosaurs | $43,113 | -66.9% | 102 | -116 | $422 | $42,221,579 | 10 | 20th Century Fox International | false | false |
| 12 | 9 | The Proposal | $38,951 | -56% | 85 | -46 | $458 | $6,729,959 | 9 | Walt Disney Pictures | false | false |
| 13 | 10 | Shorts | $36,224 | -58.2% | 60 | -1 | $603 | $142,175 | 2 | Warner Bros. | false | false |
| 14 | 11 | Harry Potter and the Half-Blood Prince | $33,919 | -23.6% | 45 | -29 | $753 | $18,824,485 | 8 | Warner Bros. | false | false |
| 15 | - | Antichrist | $28,701 | - | 14 | - | $2,050 | $95,966 | 2 | N/A | false | false |
| 16 | - | The Wedding Song | $16,470 | - | 15 | - | $1,098 | $16,470 | 1 | Paris Filmes | true | false |
| 17 | 15 | The Story of Me | $15,963 | -35.8% | 52 | -10 | $306 | $497,905 | 5 | Warner Bros. | false | false |
| 18 | 13 | The Invisible Woman | $14,565 | -50.2% | 48 | -22 | $303 | $10,629,849 | 14 | Warner Bros. | false | false |
| 19 | - | The Wave | $14,529 | - | 17 | - | $854 | $75,236 | 3 | N/A | false | false |
| 20 | 16 | Last Chance Harvey | $12,597 | -42.8% | 19 | -8 | $663 | $748,954 | 12 | N/A | false | false |
| 21 | 12 | The Accidental Husband | $10,745 | -71.9% | 51 | -44 | $210 | $1,029,406 | 5 | PlayArte Pictures | false | false |
| 22 | 14 | Time of Peace | $10,674 | -62.3% | 27 | -24 | $395 | $332,449 | 4 | N/A | false | false |
| 23 | - | Veronika Decides to Die | $6,620 | - | 17 | - | $389 | $154,837 | 3 | N/A | false | false |
| 24 | 17 | Public Enemies | $6,276 | -68.8% | 23 | -27 | $272 | $2,683,490 | 7 | Universal Pictures International (UPI) | false | false |
| 25 | - | Adrift | $6,232 | - | 19 | - | $328 | $394,039 | 6 | Universal Pictures International (UPI) | false | false |
| 26 | 19 | The Butterfly Effect 3: Revelations | $6,149 | -66.4% | 18 | -23 | $341 | $577,958 | 6 | N/A | false | false |
| 27 | - | Departures | $3,920 | - | 8 | - | $490 | $379,094 | 14 | Paris Filmes | false | false |
| 28 | - | Giant | $3,672 | - | 7 | - | $524 | $39,856 | 3 | N/A | false | false |
| 29 | 18 | Doomsday | $3,045 | -84.7% | 19 | -37 | $160 | $138,778 | 3 | Europa Filmes | false | false |
| 30 | - | Halloween | $2,950 | - | 15 | - | $196 | $728,550 | 7 | PlayArte Pictures | false | false |
| 31 | - | The Milk of Sorrow | $1,719 | - | 7 | - | $245 | $33,007 | 3 | Paris Filmes | false | false |
| 32 | - | The International | $1,552 | - | 10 | - | $155 | $620,479 | 12 | Sony Pictures Releasing | false | false |
| 33 | - | 17 Again | $1,446 | - | 14 | - | $103 | $1,326,781 | 9 | PlayArte Pictures | false | false |
| 34 | - | Hannah Montana: The Movie | $448 | - | 5 | - | $89 | $2,609,525 | 13 | Walt Disney Pictures | false | false |
| 35 | - | The Girlfriend Experience | $412 | - | 5 | - | $82 | $54,474 | 4 | Paris Filmes | false | false |
| 36 | - | Angels & Demons | $382 | - | 1 | - | $382 | $13,858,975 | 17 | Sony Pictures Releasing | false | false |
| 37 | - | Waltz with Bashir | $92 | - | 2 | - | $46 | $110,902 | 23 | Sony Pictures Releasing | false | false |
| 38 | - | Frozen River | $76 | - | 2 | - | $38 | $49,080 | 29 | Sony Pictures Releasing | false | false |
