| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $489,287 | -54.9% | 144 | -19 | $3,397 | $2,809,089 | 2 | Warner Bros. | false | false |
| 2 | - | Gamer | $291,521 | - | 44 | - | $6,625 | $291,521 | 1 | Odeon | true | false |
| 3 | 2 | Inglourious Basterds | $241,531 | -38.9% | 66 | - | $3,659 | $1,668,413 | 3 | United International Pictures | false | false |
| 4 | 3 | Ice Age: Dawn of the Dinosaurs | $101,766 | +34% | 44 | -10 | $2,312 | $4,483,424 | 10 | 20th Century Fox International | false | false |
| 5 | - | The Soloist | $99,639 | - | 26 | - | $3,832 | $99,639 | 1 | United International Pictures | true | false |
| 6 | - | The Time Traveler's Wife | $73,626 | - | 27 | - | $2,726 | $73,626 | 1 | Roadshow Films | true | false |
| 7 | 5 | The Hangover | $39,514 | -35.1% | 20 | -9 | $1,975 | $2,682,479 | 8 | Warner Bros. | false | false |
| 8 | 4 | I Hate Valentine's Day | $35,668 | -47.4% | 21 | -1 | $1,698 | $342,569 | 3 | Odeon | false | false |
| 9 | - | Aliens in the Attic | $32,052 | - | 14 | - | $2,289 | $32,052 | 1 | 20th Century Fox International | true | false |
| 10 | - | Wild Blood | $10,060 | - | 2 | - | $5,030 | $10,060 | 1 | Spentzos Films | true | false |
| 11 | 7 | The Taking of Pelham 123 | $3,926 | -77.3% | 5 | -7 | $785 | $505,364 | 7 | Sony Pictures Releasing | false | false |
