| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Final Destination | $349,507 | - | 41 | - | $8,524 | $561,962 | 1 | Warner Bros. | true | false |
| 2 | 1 | Inglourious Basterds | $301,560 | -33.2% | 65 | - | $4,639 | $3,557,696 | 5 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $86,911 | -37.1% | 74 | -1 | $1,174 | $8,916,317 | 12 | 20th Century Fox International | false | false |
| 4 | 4 | G-Force | $77,875 | -33.3% | 71 | -2 | $1,096 | $2,311,672 | 8 | Walt Disney Pictures | false | false |
| 5 | 3 | Gamer | $73,936 | -40.5% | 34 | - | $2,174 | $232,658 | 2 | Benelux Film Distributors | false | false |
| 6 | 6 | The Over the Hill Band | $66,892 | -25.9% | 24 | - | $2,787 | $570,305 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 7 | 7 | A Perfect Getaway | $64,999 | -23.8% | 23 | - | $2,826 | $449,790 | 4 | A-Film Distribution | false | false |
| 8 | - | The Young Victoria | $57,757 | - | 26 | - | $2,221 | $72,722 | 1 | Paradiso Entertainment | true | false |
| 9 | 5 | Harry Potter and the Half-Blood Prince | $53,431 | -43.2% | 85 | -13 | $628 | $8,812,824 | 10 | Warner Bros. | false | false |
| 10 | 8 | Public Enemies | $42,643 | -37.1% | 42 | -7 | $1,015 | $2,320,123 | 9 | Universal Pictures International (UPI) | false | false |
| 11 | - | My Life in Ruins | $39,217 | - | 12 | - | $3,268 | $51,585 | 1 | Belga Films | true | false |
| 12 | 9 | The Taking of Pelham 123 | $38,601 | -33.3% | 26 | -5 | $1,484 | $1,409,218 | 8 | Sony Pictures Releasing | false | false |
| 13 | 11 | The Proposal | $38,144 | -21% | 27 | -1 | $1,412 | $2,808,122 | 14 | Walt Disney Pictures | false | false |
| 14 | 12 | A Prophet | $37,026 | -19.1% | 22 | -3 | $1,683 | $264,402 | 4 | ABC Distribution | false | false |
| 15 | - | Antichrist | $35,120 | - | 12 | - | $2,926 | $41,813 | 1 | N/A | true | false |
| 16 | - | 9 | $34,903 | - | 14 | - | $2,493 | $43,089 | 1 | A-Film Distribution | true | false |
| 17 | 10 | G.I. Joe: The Rise of Cobra | $31,971 | -42.4% | 34 | -10 | $940 | $1,573,052 | 7 | Universal Pictures International (UPI) | false | false |
| 18 | 13 | Neuilly Yo Mama! | $31,302 | -30.7% | 10 | -5 | $3,130 | $322,959 | 5 | Les Films de l'Elysée | false | false |
| 19 | 14 | The Hangover | $30,311 | -9% | 10 | - | $3,031 | $1,962,883 | 14 | Warner Bros. | false | false |
| 20 | 17 | Het geheim van Mega Mindy | $17,375 | -30.3% | 27 | - | $643 | $1,573,758 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 21 | - | The September Issue | $14,059 | - | 3 | - | $4,686 | $14,219 | 1 | Benelux Film Distributors | true | false |
| 22 | 16 | Regrets | $13,621 | -50.2% | 10 | - | $1,362 | $55,996 | 2 | Benelux Film Distributors | false | false |
| 23 | 23 | The Hedgehog | $11,499 | -15.8% | 11 | - | $1,045 | $239,153 | 7 | Cinéart | false | false |
| 24 | 19 | Le coach | $9,799 | -56.2% | 16 | -1 | $612 | $42,602 | 2 | N/A | false | false |
| 25 | 21 | Partir | $9,610 | -55.3% | 16 | -1 | $600 | $287,135 | 6 | Benelux Film Distributors | false | false |
| 26 | 22 | The Time That Remains | $8,998 | -36.1% | 6 | - | $1,499 | $26,807 | 2 | Cinéart | false | false |
| 27 | 20 | Bandslam | $8,742 | -60.1% | 22 | -9 | $397 | $399,488 | 6 | Belga Films | false | false |
| 28 | 18 | Easy Virtue | $8,279 | -64.7% | 8 | - | $1,034 | $116,428 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 29 | - | Holy Money | $6,924 | - | 5 | - | $1,384 | $6,924 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 30 | 25 | I Love You, Man | $5,735 | -36.9% | 6 | - | $955 | $361,312 | 8 | Universal Pictures International (UPI) | false | false |
| 31 | 35 | Passengers | $4,929 | +37.1% | 3 | - | $1,643 | $101,260 | 8 | Paradiso Entertainment | false | false |
| 32 | 30 | Angels & Demons | $3,671 | -31.9% | 2 | - | $1,835 | $4,689,109 | 19 | Sony Pictures Releasing | false | false |
| 33 | 33 | Drag Me to Hell | $3,659 | -11.2% | 4 | -1 | $914 | $619,659 | 13 | Belga Films | false | false |
| 34 | - | A Summer in Genoa | $3,145 | - | 3 | - | $1,048 | $4,233 | 1 | A-Film Distribution | true | false |
| 35 | 34 | Ghosts of Girlfriends Past | $3,008 | -19.2% | 3 | -1 | $1,002 | $589,286 | 12 | Kinepolis Film Distribution (KFD) | false | false |
| 36 | 28 | Lost Persons Area | $2,979 | -54.1% | 8 | - | $372 | $12,860 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 37 | 38 | State of Play | $2,545 | -13.4% | 2 | -3 | $1,272 | $568,387 | 14 | Universal Pictures International (UPI) | false | false |
| 38 | 24 | Brüno | $2,127 | -82.8% | 6 | -9 | $354 | $2,289,718 | 11 | Universal Pictures International (UPI) | false | false |
| 39 | 26 | The Haunting in Connecticut | $2,118 | -75.4% | 4 | -8 | $529 | $233,777 | 7 | Benelux Film Distributors | false | false |
| 40 | 27 | Hannah Montana: The Movie | $2,077 | -75.3% | 12 | -1 | $173 | $663,471 | 11 | Walt Disney Pictures | false | false |
| 41 | 40 | Fighting | $1,962 | -16.4% | 1 | -3 | $1,962 | $252,440 | 10 | Universal Pictures International (UPI) | false | false |
| 42 | 37 | Amreeka | $1,807 | -44.7% | 10 | - | $180 | $63,519 | 6 | Cinéart | false | false |
| 43 | 29 | Goodbye Solo | $1,750 | -67.5% | 4 | -1 | $437 | $28,318 | 4 | N/A | false | false |
| 44 | 36 | Princess Lillifee | $1,156 | -65.7% | 2 | -3 | $578 | $54,690 | 26 | Walt Disney Pictures | false | false |
| 45 | 39 | Coraline | $1,146 | -52.2% | 3 | -3 | $382 | $501,453 | 15 | Universal Pictures International (UPI) | false | false |
| 46 | 32 | Demain | $1,078 | -78% | 7 | -1 | $154 | $23,200 | 3 | Benelux Film Distributors | false | false |
| 47 | 42 | Blind Mountain 2009 Re-release | $1,068 | -0.6% | 1 | - | $1,068 | $6,732 | 2 | Cinéart | false | false |
| 48 | 31 | Transformers: Revenge of the Fallen | $987 | -80.2% | 2 | -5 | $493 | $2,966,507 | 13 | Universal Pictures International (UPI) | false | false |
