| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Inglourious Basterds | $642,587 | -32.6% | 81 | +1 | $7,933 | $3,654,609 | 3 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | The Final Destination | $442,173 | -32.2% | 59 | +2 | $7,494 | $1,300,909 | 2 | Warner Bros. | false | false |
| 3 | 3 | Harry Potter and the Half-Blood Prince | $170,641 | -36.7% | 153 | -9 | $1,115 | $16,067,892 | 9 | Warner Bros. | false | false |
| 4 | 4 | My Sister's Keeper | $153,616 | -23.7% | 38 | - | $4,042 | $794,044 | 3 | Warner Bros. | false | false |
| 5 | 5 | G-Force | $130,201 | -32% | 103 | -2 | $1,264 | $2,460,536 | 7 | Walt Disney Pictures | false | false |
| 6 | 6 | The Taking of Pelham 123 | $128,402 | -28.5% | 70 | - | $1,834 | $1,282,263 | 4 | Sony Pictures Releasing | false | false |
| 7 | 7 | Ice Age: Dawn of the Dinosaurs | $119,019 | -32.3% | 125 | -15 | $952 | $12,550,824 | 11 | 20th Century Fox International | false | false |
| 8 | 8 | The Girl with the Dragon Tattoo | $85,095 | -32.5% | 41 | +1 | $2,075 | $1,126,462 | 6 | Benelux Film Distributors | false | false |
| 9 | 9 | Funny People | $79,364 | -26.3% | 30 | - | $2,645 | $253,342 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 11 | The Hangover | $66,415 | -19.7% | 50 | +3 | $1,328 | $5,093,217 | 14 | Warner Bros. | false | false |
| 11 | 10 | Public Enemies | $58,108 | -36.2% | 69 | -6 | $842 | $2,459,994 | 7 | Universal Pictures International (UPI) | false | false |
| 12 | 14 | The Proposal | $52,875 | -18.8% | 54 | -1 | $979 | $4,283,762 | 13 | Walt Disney Pictures | false | false |
| 13 | - | Passengers | $49,127 | - | 7 | - | $7,018 | $50,580 | 1 | Paradiso Entertainment | true | false |
| 14 | 13 | G.I. Joe: The Rise of Cobra | $48,320 | -36% | 58 | -9 | $833 | $1,334,290 | 5 | United International Pictures | false | false |
| 15 | 12 | Broken Embraces | $47,514 | -37.5% | 23 | - | $2,065 | $270,128 | 3 | Cinéart | false | false |
| 16 | 15 | Lilly the Witch: The Dragon and the Magic Book | $39,385 | -33.7% | 50 | - | $787 | $251,038 | 4 | RCV Film Distribution | false | false |
| 17 | 17 | Bandslam | $33,680 | -33.3% | 40 | - | $842 | $223,868 | 3 | Independent Films | false | false |
| 18 | 16 | Het geheim van Mega Mindy | $28,514 | -46.1% | 90 | -3 | $316 | $2,214,058 | 10 | Independent Films | false | false |
| 19 | 19 | The Indian | $24,338 | -31.7% | 71 | +1 | $342 | $351,087 | 5 | A-Film Distribution | false | false |
| 20 | 18 | Luke and Lucy: The Texas Rangers | $24,312 | -39.4% | 83 | - | $292 | $825,109 | 8 | RCV Film Distribution | false | false |
