| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $486,699 | - | 88 | - | $5,530 | $549,180 | 1 | Walt Disney Pictures | true | false |
| 2 | - | The Taking of Pelham 123 | $151,006 | - | 53 | - | $2,849 | $151,006 | 1 | Sony Pictures Releasing | true | false |
| 3 | 3 | The Young Victoria | $109,295 | -0.9% | 42 | - | $2,602 | $283,855 | 2 | Roadshow Films | false | false |
| 4 | 1 | The Ugly Truth | $87,929 | -33.5% | 50 | -6 | $1,758 | $696,866 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | District 9 | $79,080 | -27.3% | 46 | -3 | $1,719 | $1,522,419 | 5 | Sony Pictures Releasing | false | false |
| 6 | 2 | Inglourious Basterds | $76,821 | -40.6% | 38 | -5 | $2,021 | $892,291 | 4 | United International Pictures | false | false |
| 7 | - | I Love You, Beth Cooper | $39,001 | - | 37 | - | $1,054 | $39,001 | 1 | 20th Century Fox International | true | false |
| 8 | - | Dance Flick | $36,755 | - | 33 | - | $1,113 | $41,918 | 1 | Paramount Pictures International | true | false |
| 9 | 5 | G.I. Joe: The Rise of Cobra | $28,304 | -54% | 39 | -11 | $725 | $1,315,977 | 6 | Paramount Pictures International | false | false |
| 10 | 8 | Sunshine Cleaning | $22,495 | -19.7% | 36 | - | $624 | $357,770 | 5 | Madman Entertainment | false | false |
| 11 | - | Is Anybody There? | $21,208 | - | 20 | - | $1,060 | $22,139 | 1 | Hopscotch Films | true | false |
| 12 | - | The September Issue | $20,808 | - | 7 | - | $2,972 | $74,790 | 1 | Madman Entertainment | true | false |
| 13 | 10 | Coco Before Chanel | $16,409 | -23.4% | 7 | - | $2,344 | $426,447 | 6 | Warner Bros. | false | false |
| 14 | 9 | Harry Potter and the Half-Blood Prince | $15,414 | -43.3% | 43 | -23 | $358 | $4,176,454 | 9 | Warner Bros. | false | false |
| 15 | 11 | The Strength of Water | $13,967 | -27.2% | 16 | -1 | $872 | $104,718 | 3 | Hopscotch Films | false | false |
| 16 | 14 | The Soloist | $12,850 | -15% | 10 | - | $1,285 | $42,112 | 2 | United International Pictures | false | false |
| 17 | 13 | Seraphine | $12,355 | -19.4% | 14 | +5 | $882 | $87,851 | 3 | Rialto Distribution | false | false |
| 18 | 18 | Departures | $11,885 | +45.7% | 7 | - | $1,697 | $91,711 | 4 | Madman Entertainment | false | false |
| 19 | 7 | Orphan | $11,281 | -65% | 20 | -16 | $564 | $141,903 | 3 | Warner Bros. | false | false |
| 20 | 16 | Separation City | $4,375 | -61.7% | 19 | -21 | $230 | $379,663 | 6 | Hoyts Distribution | false | false |
| 21 | 15 | Public Enemies | $3,608 | -70.5% | 20 | -13 | $180 | $821,444 | 7 | United International Pictures | false | false |
| 22 | 12 | Coraline | $3,586 | -80% | 22 | -18 | $163 | $320,519 | 6 | United International Pictures | false | false |
| 23 | - | Turning Point | $2,391 | - | 1 | - | $2,391 | $2,391 | 1 | N/A | true | false |
| 24 | 17 | Ice Age: Dawn of the Dinosaurs | $2,129 | -81.3% | 21 | -32 | $101 | $3,871,913 | 11 | 20th Century Fox International | false | false |
| 25 | - | Paris 36 | $2,064 | - | 5 | - | $412 | $9,438 | 2 | Sony Pictures Releasing | false | false |
| 26 | - | The Wizard of Oz 2009 NCM Fathom Event | $2,005 | - | 1 | - | $2,005 | $18,710 | 4 | - | false | false |
| 27 | 19 | The Hangover | $1,982 | -68.3% | 13 | -9 | $152 | $2,218,242 | 14 | Warner Bros. | false | false |
| 28 | - | The Burning Season | $1,881 | - | 13 | - | $144 | $1,881 | 1 | - | true | false |
| 29 | - | Bride Flight | $1,323 | - | 10 | - | $132 | $185,403 | 12 | Hopscotch Films | false | false |
| 30 | - | My Life in Ruins | $1,160 | - | 10 | - | $116 | $273,228 | 9 | 20th Century Fox International | false | false |
| 31 | - | The Proposal | $1,157 | - | 6 | - | $192 | $1,704,341 | 13 | Walt Disney Pictures | false | false |
