| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $2,936,982 | +32.5% | 434 | +126 | $6,767 | $8,328,843 | 3 | Buena Vista International | false | false |
| 2 | 2 | Funny People | $971,148 | -37.2% | 241 | - | $4,029 | $3,109,165 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | - | 500 Days of Summer | $939,601 | - | 227 | - | $4,139 | $1,093,474 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | Inglourious Basterds | $591,850 | -27% | 236 | -24 | $2,507 | $9,908,045 | 5 | Universal Pictures International (UPI) | false | false |
| 5 | - | G-Force | $533,706 | - | 176 | - | $3,032 | $680,980 | 1 | Walt Disney Pictures | true | false |
| 6 | 5 | Charlie & Boots | $349,107 | -30% | 173 | -8 | $2,017 | $2,098,146 | 3 | Paramount Pictures International | false | false |
| 7 | 6 | The Taking of Pelham 123 | $317,286 | -34.2% | 200 | -43 | $1,586 | $4,335,813 | 4 | Sony Pictures Releasing | false | false |
| 8 | 4 | Aliens in the Attic | $286,389 | -46.3% | 213 | -2 | $1,344 | $1,795,920 | 3 | 20th Century Fox International | false | false |
| 9 | 7 | The Young Victoria | $279,837 | -30% | 118 | -6 | $2,371 | $2,877,669 | 4 | Roadshow Films | false | false |
| 10 | 9 | District 9 | $213,726 | -24.6% | 116 | -10 | $1,842 | $6,641,684 | 6 | Sony Pictures Releasing | false | false |
| 11 | 8 | Push | $188,632 | -33.7% | 129 | - | $1,462 | $585,500 | 2 | Icon Film Distribution | false | false |
| 12 | 11 | Sorority Row | $120,928 | -34.5% | 113 | -6 | $1,070 | $391,145 | 2 | Hoyts Distribution | false | false |
| 13 | 10 | The Ugly Truth | $116,673 | -46.5% | 96 | -63 | $1,215 | $10,529,622 | 7 | Sony Pictures Releasing | false | false |
| 14 | 15 | The September Issue | $103,461 | -21.2% | 33 | -4 | $3,135 | $976,383 | 5 | Madman Entertainment | false | false |
| 15 | - | Dil Bole Hadippa | $85,373 | - | 12 | - | $7,114 | $85,373 | 1 | Mind Blowing Films | true | false |
| 16 | 14 | My Sister's Keeper | $75,471 | -46.3% | 84 | -50 | $898 | $8,034,157 | 8 | Roadshow Films | false | false |
| 17 | 13 | The Soloist | $72,208 | -50.2% | 74 | -23 | $975 | $712,784 | 3 | Universal Pictures International (UPI) | false | false |
| 18 | 21 | Blessed | $60,917 | +5.1% | 16 | +1 | $3,807 | $160,758 | 2 | Icon Film Distribution | false | false |
| 19 | 17 | Harry Potter and the Half-Blood Prince | $60,272 | -36.2% | 50 | +30 | $1,205 | $34,882,955 | 10 | Warner Bros. | false | false |
| 20 | 18 | Balibo | $55,892 | -39.6% | 46 | -3 | $1,215 | $915,437 | 6 | Paramount Pictures International | false | false |
| 21 | - | Valentino: The Last Emperor | $55,704 | - | 11 | - | $5,064 | $55,704 | 1 | Hopscotch Films | true | false |
| 22 | - | Shorts | $41,529 | - | 75 | - | $553 | $43,447 | 1 | Warner Bros. | true | false |
| 23 | - | Wanted | $36,323 | - | 14 | - | $2,594 | $36,323 | 1 | Eros Worldwide | true | false |
| 24 | - | Imagine That | $30,381 | - | 54 | - | $562 | $30,381 | 1 | Paramount Pictures International | true | false |
| 25 | - | $9.99 | $13,739 | - | 8 | - | $1,717 | $13,739 | 1 | Icon Film Distribution | true | false |
| 26 | - | The Marriage of Figaro | $11,872 | - | 2 | - | $5,936 | $11,872 | 1 | N/A | true | false |
