| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $1,185,903 | -20.9% | 322 | -2 | $3,682 | $6,573,295 | 3 | Walt Disney Pictures | false | false |
| 2 | - | The Ugly Truth | $1,099,736 | - | 163 | - | $6,746 | $1,257,636 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | So Normal 2: The Craziest Night Ever | $700,348 | -32.1% | 392 | -1 | $1,786 | $7,258,199 | 4 | N/A | false | false |
| 4 | 4 | The Hangover | $502,822 | -12.3% | 181 | -2 | $2,778 | $4,858,925 | 5 | Warner Bros. | false | false |
| 5 | 3 | The Taking of Pelham 123 | $459,243 | -25.7% | 181 | - | $2,537 | $2,833,777 | 3 | Sony Pictures Releasing | false | false |
| 6 | 5 | My Sister's Keeper | $178,183 | -39% | 94 | +1 | $1,895 | $611,426 | 2 | PlayArte Pictures | false | false |
| 7 | 6 | My Life in Ruins | $140,052 | -49.1% | 119 | -2 | $1,176 | $526,499 | 2 | N/A | false | false |
| 8 | 7 | G-Force | $71,510 | -25.1% | 199 | -15 | $359 | $3,862,525 | 6 | Walt Disney Pictures | false | false |
| 9 | 8 | Orphan | $70,166 | -25.9% | 76 | -1 | $923 | $523,386 | 3 | Warner Bros. | false | false |
| 10 | 10 | Two Lovers | $39,987 | -19.1% | 37 | -4 | $1,080 | $456,001 | 4 | PlayArte Pictures | false | false |
| 11 | - | Che: Part Two | $29,791 | - | 34 | - | $876 | $29,791 | 1 | Europa Filmes | true | false |
| 12 | 9 | Bandslam | $27,847 | -55.4% | 82 | +1 | $339 | $103,402 | 2 | Paris Filmes | false | false |
| 13 | 14 | Antichrist | $21,204 | +2.4% | 13 | +2 | $1,631 | $170,453 | 4 | N/A | false | false |
| 14 | 13 | The Proposal | $17,245 | -16.9% | 51 | -6 | $338 | $6,808,777 | 11 | Walt Disney Pictures | false | false |
| 15 | 12 | Brüno | $16,950 | -32.2% | 44 | -3 | $385 | $1,127,703 | 6 | Sony Pictures Releasing | false | false |
| 16 | 22 | Doomsday | $16,427 | +104.5% | 33 | +7 | $497 | $169,033 | 5 | Europa Filmes | false | false |
| 17 | 20 | Time of Peace | $13,415 | +25.2% | 39 | +9 | $343 | $375,462 | 6 | N/A | false | false |
| 18 | 16 | The Wave | $12,283 | -31.8% | 15 | - | $818 | $126,199 | 5 | N/A | false | false |
| 19 | 15 | G.I. Joe: The Rise of Cobra | $11,724 | -34.9% | 42 | -19 | $279 | $3,262,690 | 7 | Paramount Pictures International | false | false |
| 20 | 19 | Harry Potter and the Half-Blood Prince | $11,189 | -32.7% | 16 | -14 | $699 | $18,877,223 | 10 | Warner Bros. | false | false |
| 21 | 29 | Adrift | $11,014 | +134.4% | 26 | +8 | $423 | $418,996 | 8 | Universal Pictures International (UPI) | false | false |
| 22 | 18 | Ice Age: Dawn of the Dinosaurs | $9,372 | -43.7% | 51 | -24 | $183 | $42,304,221 | 12 | 20th Century Fox International | false | false |
| 23 | 21 | Last Chance Harvey | $8,886 | -6.9% | 27 | +4 | $329 | $782,450 | 14 | N/A | false | false |
| 24 | 26 | Giant | $6,361 | +16.3% | 12 | +4 | $530 | $59,261 | 5 | N/A | false | false |
| 25 | 25 | The Butterfly Effect 3: Revelations | $5,533 | -14.2% | 23 | -1 | $240 | $597,614 | 8 | N/A | false | false |
| 26 | 23 | The Story of Me | $5,479 | -18.8% | 22 | -12 | $249 | $528,627 | 7 | Warner Bros. | false | false |
| 27 | 27 | The Accidental Husband | $5,089 | -1.3% | 35 | +4 | $145 | $1,050,380 | 7 | PlayArte Pictures | false | false |
| 28 | 30 | Veronika Decides to Die | $4,500 | -0.9% | 24 | +2 | $187 | $170,702 | 5 | N/A | false | false |
| 29 | 28 | Departures | $3,576 | -30% | 7 | -2 | $510 | $394,224 | 16 | Paris Filmes | false | false |
| 30 | 24 | The Invisible Woman | $3,412 | -47.9% | 22 | -5 | $155 | $10,660,237 | 16 | Warner Bros. | false | false |
| 31 | 31 | The Wedding Song | $1,668 | -59% | 4 | -8 | $417 | $36,330 | 3 | Paris Filmes | false | false |
| 32 | 34 | The International | $1,476 | +197.6% | 10 | +5 | $147 | $623,821 | 14 | Sony Pictures Releasing | false | false |
| 33 | - | The Assailant | $271 | - | 1 | - | $271 | $271 | - | Walt Disney Pictures | - | false |
| 34 | 36 | Frozen River | $89 | -8.2% | 2 | - | $44 | $49,384 | 31 | Sony Pictures Releasing | false | false |
| 35 | 35 | Hannah Montana: The Movie | $85 | -77.2% | 2 | -2 | $42 | $2,610,600 | 15 | Walt Disney Pictures | false | false |
| 36 | 37 | Waltz with Bashir | $65 | +124.1% | 1 | - | $65 | $111,153 | 25 | Sony Pictures Releasing | false | false |
