| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $3,028,262 | +3.1% | 431 | -3 | $7,026 | $13,396,267 | 4 | Buena Vista International | false | false |
| 2 | - | Fame | $1,494,294 | - | 227 | - | $6,582 | $1,494,294 | 1 | Icon Film Distribution | true | false |
| 3 | - | Surrogates | $1,316,892 | - | 206 | - | $6,392 | $1,316,892 | 1 | Walt Disney Pictures | true | false |
| 4 | 5 | G-Force | $1,081,566 | +102.7% | 255 | +79 | $4,241 | $2,547,921 | 2 | Walt Disney Pictures | false | false |
| 5 | 3 | 500 Days of Summer | $712,592 | -24.2% | 226 | -1 | $3,153 | $2,336,887 | 2 | 20th Century Fox International | false | false |
| 6 | 2 | Funny People | $656,199 | -32.4% | 231 | -10 | $2,840 | $4,223,700 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | 4 | Inglourious Basterds | $412,329 | -30.3% | 187 | -49 | $2,204 | $10,625,851 | 6 | Universal Pictures International (UPI) | false | false |
| 8 | 8 | Aliens in the Attic | $316,340 | +10.5% | 201 | -12 | $1,573 | $2,405,903 | 4 | 20th Century Fox International | false | false |
| 9 | 6 | Charlie & Boots | $263,601 | -24.5% | 154 | -19 | $1,711 | $2,565,474 | 4 | Paramount Pictures International | false | false |
| 10 | 9 | The Young Victoria | $202,830 | -27.5% | 108 | -10 | $1,878 | $3,250,594 | 5 | Roadshow Films | false | false |
| 11 | 7 | The Taking of Pelham 123 | $147,446 | -53.5% | 103 | -97 | $1,431 | $4,649,718 | 5 | Sony Pictures Releasing | false | false |
| 12 | 10 | District 9 | $144,846 | -32.2% | 93 | -23 | $1,557 | $6,896,244 | 7 | Sony Pictures Releasing | false | false |
| 13 | 22 | Shorts | $116,688 | +181% | 106 | +31 | $1,100 | $286,973 | 2 | Warner Bros. | false | false |
| 14 | - | Looking for Eric | $87,883 | - | 22 | - | $3,994 | $123,755 | 1 | Icon Film Distribution | true | false |
| 15 | 14 | The September Issue | $84,528 | -18.3% | 32 | -1 | $2,641 | $1,112,265 | 6 | Madman Entertainment | false | false |
| 16 | 11 | Push | $74,591 | -60.5% | 128 | -1 | $582 | $765,880 | 3 | Icon Film Distribution | false | false |
| 17 | 19 | Harry Potter and the Half-Blood Prince | $51,866 | -13.9% | 36 | -14 | $1,440 | $34,999,141 | 11 | Warner Bros. | false | false |
| 18 | 21 | Valentino: The Last Emperor | $51,516 | -7.5% | 11 | - | $4,683 | $165,467 | 2 | Hopscotch Films | false | false |
| 19 | 18 | Blessed | $49,328 | -19% | 17 | +1 | $2,901 | $237,752 | 3 | Icon Film Distribution | false | false |
| 20 | 12 | Sorority Row | $47,926 | -60.4% | 50 | -63 | $958 | $511,247 | 3 | Hoyts Distribution | false | false |
| 21 | - | Van Diemen's Land | $34,648 | - | 9 | - | $3,849 | $34,648 | 1 | Madman Entertainment | true | false |
| 22 | - | What's Your Raashee? | $26,951 | - | 12 | - | $2,245 | $26,951 | 1 | Mind Blowing Films | true | false |
| 23 | - | Seraphine | $22,149 | - | 5 | - | $4,429 | $22,149 | 1 | Rialto Distribution | true | false |
| 24 | - | Stoned Bros | $19,694 | - | 24 | - | $820 | $19,694 | 1 | N/A | true | false |
| 25 | - | Paper Heart | $6,351 | - | 4 | - | $1,587 | $6,351 | 1 | N/A | true | false |
