| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $2,629,765 | -13.2% | 410 | -21 | $6,414 | $18,129,939 | 5 | Buena Vista International | false | false |
| 2 | - | Mao's Last Dancer | $2,380,683 | - | 266 | - | $8,949 | $2,380,683 | 1 | Roadshow Films | true | false |
| 3 | 4 | G-Force | $1,658,529 | +53.3% | 350 | +95 | $4,738 | $5,371,124 | 3 | Walt Disney Pictures | false | false |
| 4 | 2 | Fame | $997,552 | -33.2% | 288 | +61 | $3,463 | $3,373,130 | 2 | Icon Film Distribution | false | false |
| 5 | 3 | Surrogates | $986,761 | -25.1% | 206 | - | $4,790 | $2,964,282 | 2 | Walt Disney Pictures | false | false |
| 6 | 5 | 500 Days of Summer | $537,680 | -24.5% | 222 | -4 | $2,421 | $3,287,728 | 3 | 20th Century Fox International | false | false |
| 7 | 6 | Funny People | $474,276 | -27.7% | 202 | -29 | $2,347 | $5,054,673 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Inglourious Basterds | $326,834 | -20.7% | 162 | -25 | $2,017 | $11,127,163 | 7 | Universal Pictures International (UPI) | false | false |
| 9 | 8 | Aliens in the Attic | $308,029 | -2.6% | 190 | -11 | $1,621 | $3,021,480 | 5 | 20th Century Fox International | false | false |
| 10 | - | Julie & Julia | $307,546 | - | 219 | - | $1,404 | $332,001 | - | Sony Pictures Releasing | - | false |
| 11 | 13 | Shorts | $196,207 | +68.1% | 150 | +44 | $1,308 | $653,973 | 3 | Warner Bros. | false | false |
| 12 | 9 | Charlie & Boots | $165,815 | -37.1% | 122 | -32 | $1,359 | $2,873,435 | 5 | Paramount Pictures International | false | false |
| 13 | 10 | The Young Victoria | $112,834 | -44.4% | 85 | -23 | $1,327 | $3,478,118 | 6 | Roadshow Films | false | false |
| 14 | 12 | District 9 | $92,314 | -36.3% | 75 | -18 | $1,230 | $7,037,796 | 8 | Sony Pictures Releasing | false | false |
| 15 | 11 | The Taking of Pelham 123 | $67,751 | -54.1% | 55 | -48 | $1,231 | $4,775,382 | 6 | Sony Pictures Releasing | false | false |
| 16 | 14 | Looking for Eric | $64,456 | -26.7% | 22 | - | $2,929 | $227,698 | 2 | Icon Film Distribution | false | false |
| 17 | 15 | The September Issue | $60,533 | -28.4% | 28 | -4 | $2,161 | $1,210,385 | 7 | Madman Entertainment | false | false |
| 18 | - | Wake Up Sid | $55,943 | - | 11 | - | $5,085 | $68,189 | 1 | Mind Blowing Films | true | false |
| 19 | - | Imagine That | $50,955 | - | 84 | - | $606 | $241,861 | 3 | Paramount Pictures International | false | false |
| 20 | 17 | Harry Potter and the Half-Blood Prince | $47,761 | -7.9% | 26 | -10 | $1,836 | $34,954,004 | 12 | Warner Bros. | false | false |
| 21 | - | Che: Part One | $15,092 | - | 5 | - | $3,018 | $15,092 | 1 | Paramount Pictures International | true | false |
| 22 | - | Che: Part Two | $3,071 | - | 5 | - | $614 | $3,071 | 1 | Paramount Pictures International | true | false |
