| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cloudy with a Chance of Meatballs | $274,575 | - | 41 | - | $6,696 | $288,740 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Inglourious Basterds | $175,734 | - | 24 | - | $7,322 | $197,592 | 1 | United International Pictures | true | false |
| 3 | 1 | The Ugly Truth | $170,704 | -29.8% | 30 | - | $5,690 | $476,391 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | Surrogates | $49,419 | -69.4% | 22 | -8 | $2,246 | $835,989 | 3 | Walt Disney Pictures | false | false |
| 5 | 3 | Whiteout | $21,685 | -78.1% | 16 | -10 | $1,355 | $155,240 | 2 | Warner Bros. | false | false |
| 6 | 4 | G.I. Joe: The Rise of Cobra | $15,129 | -41.1% | 6 | -1 | $2,521 | $2,137,286 | 11 | United International Pictures | false | false |
| 7 | 6 | Public Enemies | $6,217 | -68.7% | 4 | -3 | $1,554 | $717,711 | 13 | United International Pictures | false | false |
| 8 | 8 | Star Trek | $3,235 | -20.8% | 2 | - | $1,617 | $1,055,651 | 19 | United International Pictures | false | false |
| 9 | 10 | Harry Potter and the Half-Blood Prince | $2,701 | +250.8% | 2 | +1 | $1,350 | $3,713,801 | 14 | Warner Bros. | false | false |
