| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Ugly Truth | $286,408 | - | 54 | - | $5,303 | $286,408 | 1 | N/A | true | false |
| 2 | 1 | Up | $111,464 | -38.3% | 68 | +1 | $1,639 | $1,674,775 | 5 | Ster-Kinekor Pictures | false | false |
| 3 | 2 | The Final Destination | $97,199 | -34.3% | 33 | - | $2,945 | $313,899 | 2 | N/A | false | false |
| 4 | 3 | The Taking of Pelham 123 | $76,654 | -24.7% | 66 | +1 | $1,161 | $591,843 | 3 | N/A | false | false |
| 5 | 4 | Fame | $45,861 | -45.2% | 61 | - | $751 | $506,612 | 3 | N/A | false | false |
| 6 | 5 | Imagine That | $39,665 | -41.7% | 42 | - | $944 | $357,890 | 3 | N/A | false | false |
| 7 | 7 | Last Chance Harvey | $34,331 | -16.8% | 15 | - | $2,288 | $100,153 | 2 | N/A | false | false |
| 8 | - | Blood: The Last Vampire | $33,187 | - | 25 | - | $1,327 | $33,187 | 1 | N/A | true | false |
| 9 | 6 | Aliens in the Attic | $32,207 | -37.6% | 20 | - | $1,610 | $93,545 | 2 | N/A | false | false |
| 10 | 8 | District 9 | $23,617 | -42.4% | 32 | -18 | $738 | $1,267,861 | 7 | Ster-Kinekor Pictures | false | false |
| 11 | 12 | The Time Traveler's Wife | $15,866 | -29.9% | 29 | -9 | $547 | $366,536 | 5 | NuMetro Distribution | false | false |
| 12 | 11 | Tinker Bell and the Lost Treasure | $15,561 | -38.1% | 24 | -7 | $648 | $47,555 | 2 | N/A | false | false |
| 13 | 10 | The Proposal | $14,746 | -42.3% | 22 | -5 | $670 | $2,722,646 | 14 | Ster-Kinekor Pictures | false | false |
| 14 | 9 | G.I. Joe: The Rise of Cobra | $10,988 | -60.1% | 28 | -16 | $392 | $1,315,813 | 9 | United International Pictures | false | false |
| 15 | 13 | My Sister's Keeper | $10,078 | -43.7% | 23 | -7 | $438 | $830,357 | 9 | NuMetro Distribution | false | false |
| 16 | - | Looking for Eric | $10,008 | - | 21 | - | $476 | $10,008 | 1 | N/A | true | false |
| 17 | 18 | Wake Up Sid | $7,154 | -14.9% | 7 | - | $1,022 | $17,891 | 2 | N/A | false | false |
| 18 | - | Coco Before Chanel | $5,782 | - | 7 | - | $826 | $164,027 | 7 | NuMetro Distribution | false | false |
| 19 | 16 | Public Enemies | $5,617 | -47% | 16 | -9 | $351 | $408,612 | 6 | United International Pictures | false | false |
| 20 | 19 | Dance Flick | $3,259 | -37.4% | 8 | -2 | $407 | $66,749 | 5 | United International Pictures | false | false |
| 21 | 21 | Disgrace | $1,201 | +2.3% | 3 | +1 | $400 | $70,957 | 9 | United International Pictures | false | false |
| 22 | 20 | Adoration | $137 | -91.1% | 2 | -3 | $68 | $11,307 | 4 | United International Pictures | false | false |
